Integrated Nanofluidic BioMEMS for Biomedical Diagnostics and Analysis

用于生物医学诊断和分析的集成纳米流体 BioMEMS

• 批准号: 7896440
• 负责人: Emil P Kartalov
• 金额: $ 24.5万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7896440
• 关键词: Blood Proteins; Blood Tests; Calibration; Childhood; Complex; DNA Microarray Chip; Data; Development; Devices; Diagnostic; Early Diagnosis; Ferritin; Fingers; Fluorescence; Forensic Medicine; Gold; Healthcare; Hematoma; Human; Immunoassay; Infant; Intercalating Agents; Life; Malignant Neoplasms; Measurement; Measures; Mentors; Microfluidics; Modems; Patients; Plasma; Publishing; Research; Sampling; Savings; Screening procedure; Sensitivity and Specificity; Serum; Solutions; Spottings; System; Techniques; Test Result; Time; Vascular Endothelial Growth Factors; Venous blood sampling; cost; nanofluidic; nanomedicine; novel; point-of-care diagnostics; viral detection

Mentored section: As part of the mentored project, the candidate would extend his published results of high-throughput multiantigen fluorescence microfluidic immunoassays (BioTechniques 40: 85-90) to more complex samples, such as human blood serum and plasma, thereby paving the way to portable microfluidic blood test systems. Relevance: Portable microfluidic blood tests would produce major savings in cost and time in modern biomedical diagnostics with concomitant savings in healthcare in general. Such systems would also use finger-prick amounts of sample, eliminating the need for phlebotomy and the danger of hematomas, as well as making blood tests more accessible to pediatric patients, particularly infants. Low costs and small amounts of sample would also mean more frequent and ubiquitous testing, resulting in earlier diagnosis and thus saving lives. Independent research section: The applicant has a detailed plan outlined further below and including microfluidic immunoassays for viral detection, nanodetector and microfluidics integration for portable diagnostic devices, devices for large-scale cellular screening, on-chip PCR machine for on-the-spot forensic analysis, nested bioarrays for nanomedicine chips, DNA intercalator-separator of unknown samples, and a microfluidic cellular transfector.

指导部分:

项目成果

Quantitative modeling of the behaviour of microfluidic autoregulatory devices.

• DOI: 10.1039/c2lc20956j
• 发表时间: 2012-04-24
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Chang HJ;Ye W;Kartalov EP
• 通讯作者: Kartalov EP