Integrated Nanofluidic BioMEMS for Biomedical Diagnostics and Analysis

用于生物医学诊断和分析的集成纳米流体 BioMEMS

• 批准号: 7322537
• 负责人: Emil P Kartalov
• 金额: $ 9万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7322537
• 关键词: Antigens; Blood; Blood Proteins; Blood Tests; Calibration; Childhood; Complex; DNA Microarray Chip; Data; Development; Devices; Diagnostic; Early Diagnosis; Ferritin; Fingers; Fluorescence; Forensic Medicine; Gold; Healthcare; Hematoma; Human; Immunoassay; Infant; Intercalating Agents; Life; Malignant Neoplasms; Measurement; Measures; Mentors; Microfluidics; Modems; Patients; Plasma; Polymerase Chain Reaction; Publishing; Research; Sampling; Savings; Screening procedure; Sensitivity and Specificity; Serum; Solutions; Spottings; Standards of Weights and Measures; System; Techniques; Test Result; Time; Vascular Endothelial Growth Factors; Venous blood sampling; cost; cysteine rich protein; nanofluidic; nanomedicine; novel; point of care; viral detection

Mentored section: As part of the mentored project, the candidate would extend his published results of high-throughput multi- antigen fluorescence microfluidic immunoassays (BioTechniques 40: 85-90) to more complex samples, such as human blood serum and plasma, thereby paving the way to portable microfluidic blood testsystems. Relevance: Portable microfluidic blood tests would produce major savings in cost and time in modern biomedical diagnostics with concomitant savings in healthcare in general. Such systemswould also use finger-prick amounts of sample, eliminating the need for phlebotomy and the danger of hematomas, as well as making blood tests more accessible to pediatric patients, particularly infants. Low costs and small amounts of sample would also mean more frequent and ubiquitous testing, resulting in earlier diagnosis and thus saving lives. Independent research section: The applicant has a detailed plan outlined further below and including microfluidic immunoassaysfor viral detection, nanodetector and microfluidics integration for portable diagnostic devices, devices for large-scale cellular screening, on-chip PCR machine for on-the-spot forensic analysis, nested bioarrays for nanomedicine chips, DNA intercalator-separator of unknown samples, and a microfluidic cellular transfector.

辅导部分： 作为指导项目的一部分，候选人将扩展他发表的高通量多- 抗原荧光微流体免疫测定（BioTechniques 40：85-90）用于更复杂的样品，例如 作为人类血清和血浆，从而为便携式微流体血液测试系统铺平了道路。 相关性： 便携式微流控血液检测将在现代生物医学领域节省大量成本和时间。 诊断与随之而来的一般医疗保健的节省。这样的系统也会使用手指针刺这样的系统也会使用手指针刺 大量的样本，消除了静脉切开术的需要和血肿的危险，以及使 儿科患者，特别是婴儿更容易进行血液检查。低成本和少量的 样本也意味着更频繁和无处不在的测试，导致早期诊断，从而节省 生活 独立研究部门： 申请人有一个详细的计划，进一步概述如下，包括微流控免疫测定病毒 用于便携式诊断设备的检测、纳米检测器和微流体集成，用于大规模 细胞筛选，用于现场法医分析的芯片PCR仪，用于 纳米医学芯片、未知样品的DNA嵌入分离器和微流体细胞分离器。