Multispectral II-Plate Diffuse Optical Breast Tomography

多光谱 II 板漫反射光学乳腺断层扫描

• 批准号: 7270653
• 负责人: ARJUN G. YODH
• 金额: $ 42.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7270653
• 关键词: Air; Algorithms; Basic Science; Biopsy; Bite; Blood; Blood Vessels; Breast; Calibration; Cancer Patient; Cell Nucleus; Characteristics; Chest wall structure; Clinical; Clinical Data; Clinical Research; Computer software; Condition; Contrast Media; Coupling; Data; Data Set; Depth; Detection; Devices; Diagnostic; Diffuse; Disease; Engineering; Fat emulsion; Fiber Optics; Goals; Grant; Hemoglobin; Image; In Situ; Invasive; Lasers; Light; Lipids; Magnetic Resonance Imaging; Mammary Gland Parenchyma; Mammary Neoplasms; Mammography; Measurable; Measurement; Methods; Monitor; Morphologic artifacts; Nature; Neoadjuvant Therapy; Nonionizing Radiation; Numbers; Operative Surgical Procedures; Optical Image Reconstruction; Optical Methods; Optics; Other Imaging Modalities; Oxygen; Pathologist; Patients; Pennsylvania; Pharmaceutical Preparations; Physiological; Physiology; Pilot Projects; Platelet Factor 4; Pliability; Population; Positioning Attribute; Prior Chemotherapy; Process; Property; Purpose; Range; Rate; Relative (related person); Research; Resolution; Risk; Sampling; Sensitivity and Specificity; Shapes; Side; Source; Specific qualifier value; Speed; Staging; Surgeon; Techniques; Testing; Time; Tissues; Tomogram; Translations; Ultrasonography; University Hospitals; Variant; Water; Work; absorption; base; charge coupled device camera; chemotherapy; chromophore; density; design; detector; diffuse optical tomography; image reconstruction; improved; instrument; intravenous injection; malignant breast neoplasm; optical imaging; parallel computing; radiologist; reconstruction; response; simulation; size; success; tomography; transmission process; tumor

DESCRIPTION (provided by applicant): The long-range goal of this competing continuation grant is to assess and improve the breast tumor diagnostic capabilities of diffuse optical tomography with near infrared light. Near-infrared diffuse optical tomography is based on the study of functional processes, and provides several unique measurable parameters with potential to enhance breast tumor sensitivity and specificity. The techniques utilize non-ionizing radiation, are non-invasive, and are technologically simple and fast. Tissue optical absorption coefficients provide access to blood dynamics, total hemoglobin concentration, blood oxygen saturation, water concentration and lipid content. These tissue properties are often substantially different in rapidly growing tumors. During this proposal cycle we assembled a parallel-plate soft-compression apparatus for diffuse optical tomography of breast, and we have began pilot clinical studies with the instrument at the Hospital of the University of Pennsylvania. Our pilot studies have clearly shown tumors are detectable and characterizable with the diffuse optical method; they can even be tracked during neoadjuvant chemotherapy. Our proposed work emphasizes hardware and software improvements, and then pushes for more and deeper clinical studies. In particular we will upgrade the source switching apparatus and detection CCD in order to improve speed by approximately a factor of 4. This will increase our spectral coverage by approximately 4, given the same measurement time. We will upgrade the breast table to improve our idefinition of tissue boundaries and increase our sensitivity to breast tissue near the chest wall. We will upgrade our software for reconstruction in many ways, but most importantly in ways that reduce artifacts near boundaries. We will continue pilot studies on normal subjects and tumor bearing patients, this time with more specific supporting information from radiologists and pathologists, and finally, we will have a unique opportunity to follow a group of patients undergoing neoadjuvant chemotherapy. If successful, these powerful new improvements will enhance the fidelity of the breast images, and the anatomical and functional information generated by the device will improve our ability to detect and specify the nature of breast tumors.

描述(由申请人提供)： 这项竞争性延续拨款的长期目标是评估和提高近红外线漫反射光学断层扫描诊断乳腺肿瘤的能力。近红外漫反射光学断层成像是基于对功能过程的研究，提供了几个独特的可测量参数，有可能提高乳腺肿瘤的敏感性和特异性。这些技术利用非电离辐射，是非侵入性的，并且技术简单和快速。组织光吸收系数提供了血液动力学、总血红蛋白浓度、血氧饱和度、水浓度和脂肪含量的信息。在快速生长的肿瘤中，这些组织特性往往有很大不同。在这个提议周期中，我们组装了一个用于乳房漫反射光学断层扫描的平行板软压设备，我们已经在宾夕法尼亚大学医院开始了该设备的试点临床研究。我们的初步研究清楚地表明，肿瘤可以通过漫反射光学方法检测和表征；甚至可以在新辅助化疗期间进行跟踪。我们提出的工作强调硬件和软件的改进，然后推动更多和更深入的临床研究。特别是，我们将升级源开关设备和探测CCD，以便将速度提高约4倍。在相同的测量时间下，这将使我们的光谱覆盖范围增加约4倍。我们将升级乳房台面，以改善我们对组织边界的定义，并提高我们对胸壁附近乳房组织的敏感度。我们将在许多方面升级我们的重建软件，但最重要的是减少边界附近的人工制品。我们将继续对正常受试者和肿瘤患者进行试点研究，这一次将得到放射科医生和病理学家提供的更具体的支持信息，最后，我们将有一个独特的机会来跟踪一组正在接受新辅助化疗的患者。如果成功，这些强大的新改进将提高乳房图像的保真度，该设备产生的解剖和功能信息将提高我们检测和确定乳房肿瘤性质的能力。