Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children

少数民族儿童早年接触城市污染物对健康的影响

基本信息

批准号：
7209146
负责人：
FREDERICA P PERERA
金额：
$ 121.78万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7209146
关键词：
11 year old 7 year old 9 year old Adolescence Affect African American Age Age-Years Air Allergens Allergic Antigens Area Aromatic Hydrocarbons Aromatic Polycyclic Hydrocarbons Asthma Attention deficit hyperactivity disorder Behavior assessment Behavioral Behavioral Paradigm Biological Biological Markers Birth Blood Blood specimen Boxing CYP1A1 gene Canis familiaris Carbon Black Central City Child Child Behavior Child health care Childhood Childhood Asthma Chlorpyrifos Clinical Clinical assessments Cognitive Cognitive deficits Collection Communities Complex Condition Cotinine Data Demographic Factors Development Diagnosis Diagnostic Dictyoptera Disease Dust End Date Endotoxins Enrollment Environmental Health Environmental Pollution Equipment and supply inventories Ethnic Origin Evaluation Exhalation Exposure to Family Felis catus Fetal Growth Funding Future GSTM1 gene GSTP1 gene Genotype Grant Growth Head circumference Health Heavy Metals Height Home environment Hour House Dust Household Housing IgE Immunoglobulins Impairment Indium Individual Insecticides Laboratories Latina Learning Leukotrienes Life Low income Measurement Measures Mercury Metals Minority Molds Molecular Monitor Mothers Motor Mus Neurotoxins New York City Newborn Infant Numbers Nursery Schools Outcome Outcome Assessment Overweight Parents Pathogenesis Performance Pesticides Physicians Plasma Polycyclic Hydrocarbons Pregnancy Prevention Principal Investigator Problem behavior Production Pulmonary function tests Purpose Pyrenes Questionnaires Range Rate Recording of previous events Recruitment Activity Reporting Research Research Personnel Respiratory physiology Risk Risk Factors Sampling Schools Series Social Environment Specimen Symptoms System TNFRSF5 gene Testing Time Toxicant exposure Trace metal United States Environmental Protection Agency Urine Visit Washington Weight Wheezing Woman air monitoring air sampling airway inflammation base cohort cost cytokine developmental disease emotion regulation experience fluorouracil/melphalan/tamoxifen follow-up gene environment interaction glutathione S-transferase M1 glutathione S-transferase pi inner city instrument interdisciplinary approach isoprostaglandin F2alpha type-III lymphocyte proliferation neurobehavioral neurodevelopment neurotoxic pollutant postnatal prenatal prenatal exposure programs promoter psychosocial pyrene pyroglyphid respiratory response sample collection size stem toxicant urinary

项目摘要

DESCRIPTION (provided by applicant): The major objective of the proposed research is to study the impact of early-life exposures to common urban pollutants on neurobehavioral development and asthma in a sample of children living in three low-income, minority communities of New York City (Central Harlem, Washington Heights and the South Bronx). Using a molecular epidemiologic approach with monitoring, biomarkers, and clinical assessments at serial time points, we will extend our study of African-American and Latina urban mothers and children in order to follow the cohort through child age 11 years to assess the longer-term impact of exposures on child health and developmental outcomes. The exposures of concern include airborne polycyclic aromatic hydrocarbons (PAHs) and orgnaophosphate pesticides such as chlorpyrifos (CPF). The first Specific Aim (Neurodevelopmental) builds on our prior findings and proposes to evaluate relationships between early exposures (PAHs and CPF) and longer-term neurodevelopment, in order to assess the persistence of neurotoxic effects into the school years, identify effects that may emerge over time, and delve more deeply into the behavioral domains to better understand the significance of behavior problems observed in the preschool years. The second aim (Asthma) also builds on our previous findings with respect to risk factors for asthma. We will repeat the assessment of immunoglobulin (lg)E at ages 5, 7, and 9 and obtain measures of lung function and airway inflammation, and a physician-diagnosis of asthma between ages 5 and 7 years. We will also assess the association between becoming overweight in the first 5 years of life and the development of IgE, airway inflammation, and asthma in childhood. The research will consider the effect of known determinants of disease and potential confounders, including other toxic exposures and demographic factors. By using a multidisciplinary approach to understand the complex pathogenesis of developmental disorders and asthma that impose such a heavy burden on inner-city children, we anticipate that the proposed research will have important implications for prevention.

描述（由申请人提供）：拟议研究的主要目的是研究早期生活对普通城市污染物对神经行为发展和哮喘的影响。使用分子流行病学方法，通过监测，生物标志物和临床评估在串行时间点上，我们将扩展对非裔美国人和拉丁裔城市母亲和儿童的研究，以便在11岁之间跟随该同类群体，以评估暴露于儿童健康和发展的长期影响。关注的暴露包括空气中的多环芳烃（PAHS）和细胞磷酸盐农药，例如毒死rif虫（CPF）。第一个具体目标（神经发育）建立在我们先前的发现和提议的基础上，以评估早期暴露（PAH和CPF）和长期神经发育之间的关系，以评估神经毒性效应对学年的持续性，并可以随着时间的推移而逐渐深深地了解行为的巨大范围，从而使行为变得更加重要。第二个目标（哮喘）也基于我们先前关于哮喘危险因素的发现。我们将在5、7和9岁时重复评估免疫球蛋白（LG）E，并获得肺功能和气道炎症的度量，以及5至7岁之间哮喘的医师诊断。我们还将评估生命的头5年与IGE，气道炎症和儿童哮喘的发展之间的关联。该研究将考虑已知的疾病决定因素和潜在混杂因素的影响，包括其他有毒的暴露和人口统计学因素。通过使用多学科的方法来了解发育障碍和哮喘的复杂发病机理，对内城儿童施加如此沉重的负担，我们预计拟议的研究将对预防具有重要意义。