Synthesis of Novel Anticancer Agents

描述（由申请人提供）：鉴于这一领域的最新发展，用苝醌和金丝桃素结构类型进行光动力癌症治疗的潜力尤其值得注意。该计划的重点是通过模拟生物氧化系统合成这种复杂的天然产物及其类似物。通过氧化C-H键活化形成C-C键同时建立轴向手性的方法将使用手性氧化催化剂开发。在这些转换中相对于复杂的底物的选择性的可能性是显着的合成潜力。如果这些目标得以实现，可以设想用于组装天然产物的新颖且独特的合成策略。介绍了对称和不对称手性联萘、苝醌、双萘并吡喃酮、双蒽醌、金丝桃素和双黄酮等天然产物的合成路线。

DESCRIPTION (provided by applicant): The potential for photodynamic cancer therapy with the perylenequinone and hypericin structural types is especially noteworthy given recent developments in this area. The proposed program focuses on synthesis of such complex natural products and their analogs by mimicking biological oxidative systems. Methods to form C-C bonds via oxidative C-H bond activation while establishing axial chirality will be developed using chiral oxidative catalysts. The possibility of selectivity in these transformations with respect to complex substrates is of significant synthetic potential. If such goals are realized, novel and unique synthetic strategies for the assembly of natural products can be envisioned. Routes to symmetric and dissymmetric chiral binaphthyl, perylenequinone, bisnaphthopyrone, bisanthraquinone, hypericin, and bisflavone natural products are presented.