Synthesis of Novel Anticancer Agents

描述（由申请人提供）：考虑到该领域的最新发展，苝丙二烯醌和金丝桃素结构类型在光动力癌症治疗方面的潜力尤其值得注意。该计划的重点是通过模拟生物氧化系统合成这些复杂的天然产物及其类似物。利用手性氧化催化剂，通过氧化活化C-H键形成C-C键，同时建立轴向手性。选择性的可能性，在这些转化相对于复杂的底物是重要的合成潜力。如果实现这些目标，可以设想用于天然产物组装的新颖和独特的合成策略。介绍了对称和不对称手性对苯二酚，苝，双萘并吡啶酮，双蒽醌，金丝桃素和双黄酮的天然产物。

DESCRIPTION (provided by applicant): The potential for photodynamic cancer therapy with the perylenequinone and hypericin structural types is especially noteworthy given recent developments in this area. The proposed program focuses on synthesis of such complex natural products and their analogs by mimicking biological oxidative systems. Methods to form C-C bonds via oxidative C-H bond activation while establishing axial chirality will be developed using chiral oxidative catalysts. The possibility of selectivity in these transformations with respect to complex substrates is of significant synthetic potential. If such goals are realized, novel and unique synthetic strategies for the assembly of natural products can be envisioned. Routes to symmetric and dissymmetric chiral binaphthyl, perylenequinone, bisnaphthopyrone, bisanthraquinone, hypericin, and bisflavone natural products are presented.