NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：杜克大学医学院新生儿科热切地提交这份续期申请，继续参与nichd赞助的合作多中心新生儿研究网络（NRN）。NRN的目的是通过大型多中心合作试验来研究护理新生儿的治疗策略。该司对NRN研究的承诺反映在它参与研究、病人的招募和随访，以及它提交和NRN接受涉及五名杜克大学教员的项目。这些研究包括与杜克大学传染病、真菌学、普拉特工程学院和人类遗传学中心的其他研究人员合作。这些研究包括：匿名DNA库和链接数据库；新生儿念珠菌病的早期诊断围生期缺氧及脑室内出血患儿APOE水平的研究胃食管反流：新生儿网络实践。杜克大学参与了以下网络试验：光疗；围生期窒息的体冷治疗支持;PCV-7免疫原性;基准干预提高无支气管肺发育不良患者的生存率VLBW婴儿发病率和死亡率调查aEEG预测缺氧缺血性脑病预后的研究肌醇与ROP先导预防及细胞因子研究。在加入网络之前，杜克大学的教师参加了nichd赞助的高频振荡试验和预防新生儿BPD的iNO；以及业界赞助的cingi研究，针对足月婴儿肺动脉高压和围产期窒息的头部冷却研究。新生儿-围产期医学部致力于临床研究，并获得了杜克大学转化医学奖，得到了医学院的支持。我们的承诺和专业知识的进一步证据是NRN教师的参与，他们是临床研究和流行病学方面的硕士（Gotten, Herrera）和博士（Benjamin）。值得注意的是，杜克新生儿科的患者集水区在过去一年中增长了56%，因此目标是将符合NRN研究条件的患者入院率提高25%。该科设有综合多学科随访诊所，以整体方式治疗患者，特别关注营养。它与社区机构和服务机构合作，网络研究和通用数据库的患者回复率为80%。

DESCRIPTION (provided by applicant): The Division of Neonatology, Duke University School of Medicine enthusiastically submits this renewal application for continued participation in the NICHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). The NRN's purpose is to investigate treatment strategies for the care neonates through large multicenter collaborative trials. The Division's commitment to NRN research is reflected in its participation in studies, recruitment and follow-up of patients, and its submission and NRN acceptance of projects involving five Duke faculty members. These studies encompass collaborations with other Duke investigators in Infectious Diseases, Mycology, the Pratt School of Engineering and the Center for Human Genetics. These studies include: The Anonymized DNA Bank and Linked Database; Early Diagnosis of Neonatal Candidiasis; Prevalence of APOE in Infants with Perinatal Asyphxia and Intraventricular Hemorrhage; and Gastroesophageal Reflux: Neonatal Network Practices. Duke has participated in the following Network trials: Phototherapy; Body-Cooling for Perinatal Asphyxia; SUPPORT; PCV-7 Immunogenicity; Benchmarking Intervention to Increase Survival without Bronchopulmonary Dysplasia; the Survey of Morbidity and Mortality among VLBW Infants; aEEG to Predict Outcome after Hypoxic-lschemic Encephalopathy; Inositol and Prevention of ROP Pilot, and the Cytokine Studies. Prior to joining the Network, Duke faculty participated in the NICHD-sponsored High Frequency Oscillation Trial and iNO for Prevention of BPD in Premies; and the industry-sponsored CINRGI iNO Study for Term Infants with Pulmonary Hypertension and Head-Cooling for Perinatal Asphyxia studies. The Division of Neonatal-Perinatal Medicine is committed to clinical research and has the School of Medicine's support as evidenced by its receipt of the Duke Translational Medicine Award. Further evidence of our commitment and expertise is illustrated by the participation of faculty in the NRN who are Masters (Gotten, Herrera) and PhD (Benjamin) prepared in clinical research and epidemiology. Significantly, Duke Neonatology's patient catchment area has grown by 56% in the past year and as a consequence is targeted to increase admissions of patients eligible for NRN studies by 25%. The Division houses a comprehensive multidisciplinary follow-up clinic that approaches the patient in a holistic manner with special attention to nutrition. It works collaboratively with community agencies and services and has a patient return rate for Network studies and the Generic Data Base of 3 80%.