CSHL Conference on Telomeres and Telomerase

描述(申请人提供)：关于端粒和端粒酶的冷泉港实验室会议2007年5月2-6日端粒是保护真核细胞染色体末端的特殊蛋白质-DNA复合体。在大多数真核生物中，端粒包含由端粒酶逆转录酶维持的短DNA重复序列。由于端粒酶抵消了伴随线性DNA复制而产生的末端序列丢失，因此该酶是细胞长期增殖所必需的。自从人们认识到端粒动力学和端粒酶激活在人类癌症和细胞衰老中起着关键作用以来，端粒生物学领域得到了迅速发展。因此，端粒领域现在是一个高度多样化和动态的领域，代表了广泛的研究兴趣(癌症、衰老、细胞周期、减数分裂、重组、复制等)。以及大量不同的模式生物(哺乳动物、真菌、原生动物、植物)。之前四次关于端粒和端粒酶的冷泉港实验室会议，对于将这一不同的研究人员群体聚集在一起至关重要，并由于提出了大量未发表的数据而导致了激烈的讨论和协同互动。由于CSH端粒和端粒酶会议是这一快速增长领域的科学家作为一个整体进行互动的唯一机会，这次会议对该领域的未来至关重要。此外，CSH会议的形式，所有的演讲都是从提交的摘要中挑选出来的，最大限度地为新的研究人员和年轻的研究人员提供了展示他们最新的未发表作品的机会。在之前的会议上，一个国际研究小组的出席率都很高。上一次会议上的平台介绍和海报早在出版之前就介绍了该领域的主要发现。我们预计，2007年会议的出席人数也将同样多。冷泉港实验室关于端粒和端粒酶的会议，对于将这一不同的研究人员群体聚集在一起至关重要。由于提出了大量未公布的数据，2007年会议将产生热烈的讨论和协同互动。端粒是一种特殊的蛋白质-DNA复合体，保护真核染色体的末端。 自从人们认识到端粒动力学和端粒酶激活在人类癌症和细胞衰老中起着关键作用以来，端粒生物学领域得到了迅速发展。因此，端粒领域现在是一个高度多样化和动态的领域，代表了广泛的研究兴趣(癌症、衰老、细胞周期、减数分裂、重组、复制等)。以及大量不同的模式生物(哺乳动物、真菌、原生动物、植物)。

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase May 2-6, 2007 Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. Since telomerase counteracts the terminal sequence loss that accompanies replication of linear DNA, the enzyme is required for long term cellular proliferation. The field of telomere biology has grown rapidly since it was recognized that telomere dynamics and telomerase activation play a pivotal role in human cancer and in cellular senescence. As a result, the telomere field is now a highly diverse and dynamic area, representing a wide variety of research interests (cancer, aging, cell cycle, meiosis, recombination, replication, etc.) and a large number of different model organisms (mammals, fungi, protozoa, plants). The previous four Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase, were crucial in bringing together this diverse group of researchers and resulted in vigorous discussion and synergistic interactions stimulated by the presentation of a very large body of unpublished data. Since the CSH Telomere and Telomerase meeting represents the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is of the utmost importance for the future of the field. Furthermore, the format of CSH meetings, where all talks are chosen from submitted abstracts, maximizes the opportunity for new researchers and young investigators to present their most recent unpublished work. The prior meetings had a uniformly high attendance rate from an international group of researchers. The platform presentations and posters at the past meeting presented the major discoveries in the field well before publication. We anticipate that the 2007 meeting will be equally well attended. The Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase, are crucial in bringing together this diverse group of researchers. The 2007 meeting will result in vigorous discussion and synergistic interactions stimulated by the presentation of a large body of unpublished data. Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes. The field of telomere biology has grown rapidly since it was recognized that telomere dynamics and telomerase activation play a pivotal role in human cancer and in cellular senescence. As a result, the telomere field is now a highly diverse and dynamic area, representing a wide variety of research interests (cancer, aging, cell cycle, meiosis, recombination, replication, etc.) and a large number of different model organisms (mammals, fungi, protozoa, plants).