Wnt Signaling in Development and Disease

描述（由申请人提供）：Wnt基因是多种发育过程的重要调控因子，其表达或信号级联的去调控有助于许多人类疾病的进展。Wnt信号研究的进展继续影响着与人类疾病相关的广泛问题，包括癌症的病因、诊断和治疗，以及与发育、骨形成、肥胖和糖尿病相关的无数疾病。这份拨款申请概述了计划于2007年6月21日至23日在加州大学圣地亚哥分校举行的“Wnt信号在发展和疾病中的作用”会议。这次会议将在时间上和地理上补充其他关于Wnt信号的会议，并将强调基础科学与医学之间的交叉。会议的目标是鼓励更深入地了解Wnt蛋白调控的生物过程，以及这些过程的失调如何导致人类疾病。与大多数邀请几位杰出科学家进行口头报告的传统会议不同，这次会议根据提交的摘要的优点选择演讲者，从而为职业生涯早期的科学家提供了向同行的大量听众展示他们的工作的机会。

DESCRIPTION (provided by applicant): Wnt genes are essential regulators of a multitude of developmental processes and de-regulation of their expression or signaling cascade contributes to the progression of many human diseases. Advances in the study of Wnt signaling continue to impact a broad spectrum of issues related to human disease, including etiology, diagnosis and treatment of cancer and a myriad of diseases related to development, bone formation, obesity and diabetes. This grant application outlines a meeting on "Wnt signaling in Development and Disease" scheduled for June 21 and 23, 2007 at the University of California in San Diego. The meeting will complement both temporally and geographically other meetings on Wnt signaling and will emphasize the intersection between basic science and medicine. The goal of the meeting is to encourage a deeper understanding of the biological processes regulated by Wnt proteins and how de-regulation of these processes contributes to human disease. Unlike most conventional meetings, which invite several prominent scientists to give oral presentations, this meeting selects speakers based on the merit of the submitted abstracts, thus providing scientists early in their careers with the opportunity to present their work to a large audience of their peers.