2007 Microbial Population Biology

2007年微生物种群生物学

• 批准号: 7275630
• 负责人: Antony M. DEAN
• 金额: $ 0.25万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275630
• 关键词: Antibiotic Resistance; Avian Influenza; Biology; Communicable Diseases; Computational Biology; Disease; Ecology; Epidemiology; Evolution; Funding; Genetic; HIV; Human; Influenza A Virus, H5N1 Subtype; Journals; Medical Microbiology; Modeling; Molecular Biology; Mutation; Paper; Participant; Physicians; Population; Population Biology; Population Genetics; Public Health; Range; Research; Research Personnel; Science; Scientist; Severe Acute Respiratory Syndrome; Systems Biology; Time; bacterial genetics; concept; falls; infectious disease evolution; innovation; microbial; pandemic influenza

Microbial population biology covers a diverse range of cutting edge issues in the microbial sciences and beyond. Firmly founded in evolutionary biology and with a strongly integrative approach, the GRC in Microbial Population Biology attracts researchers from evolutionary biology, ecology, computational biology, molecular biology, medical microbiology and epidemiology, bacterial genetics, population genetics, and more recently, systems biology. Research at the cutting edge of this rapidly growing field is consistently innovative (high impact papers in the top journals is the norm). This application seeks funding to support a special session on the evolution of infectious disease at the 2007 meeting of the Microbial Population Biology GRC. The emergence of new kinds of infectious disease (including antibiotic resistance) is a reality. Recent years have seen the emergence of HIV, SARS and the world remains acutely aware of the possibility of a new influenza pandemic. While the study of diseases typically falls within the domain of clinicians and microbiologists, the emergence of new infectious disease is primarily a problem in evolution and ecology. Molecular biology might tell us how many mutations are needed to switch from H5N1 (bird flu) to a form that is transmissible through human populations, but it is evolutionary biology that asks about the origin of these mutations, the order in which they need to occur and the likelihood of their occurrence: from this it becomes possible to build models and make predictions. Real progress in understanding the emergence of infectious disease and antibiotic resistance (including its control) requires that physicians talk with evolutionary biologists; that theorists talk with experimentalists. We propose to bring together a diverse spectrum of scientists in order to focus on cutting edge issues. The ensuing exchange of ideas ? particularly when fuelled by open debate among the full spectrum of meeting participants ? will provoke the emergence of new concepts and approaches for the study of the emergence of infectious disease that will ultimately make a difference to what is arguably the most significant public health issue of our time.

微生物种群生物学涵盖了各种各样的前沿问题， 微生物科学和其他领域。在进化生物学中有着坚实的基础 通过强综合的方法，微生物种群中的GRC 生物学吸引了来自进化生物学、生态学、计算 生物学、分子生物学、医学微生物学和流行病学、细菌 遗传学，群体遗传学，以及最近的系统生物学。研究 在这个快速增长的领域的前沿是一贯的创新（高 在顶级期刊上发表有影响力的论文是常态）。本申请寻求资助 支持在2007年联合国大会上举行关于传染病演变的特别会议， 微生物种群生物学GRC会议。 新型传染病的出现（包括抗生素 抵抗是现实。最近几年出现了艾滋病，非典， 全世界仍然敏锐地意识到新流感的可能性 流行病虽然疾病的研究通常属于福尔斯的领域， 临床医生和微生物学家，新的传染病的出现， 主要是进化和生态学的问题。分子生物学可能告诉我们 从H5N1（禽流感）转变为 是可以在人群中传播的，但进化生物学 询问这些突变的起源，它们需要 发生和发生的可能性：由此， 建立模型并进行预测。 在理解传染病的出现方面取得了真实的进展 和抗生素耐药性（包括其控制）需要医生谈话， 理论家和实验家的对话。我们 建议汇集不同领域的科学家， 尖端问题接下来的思想交流？特别是当 在所有与会者的公开辩论的推动下？将 激发新概念和新方法的出现， 传染病的出现最终会改变 可以说是我们这个时代最重要的公共卫生问题。