2007 Microbial Population Biology

微生物种群生物学涵盖了一系列的前沿问题 微生物科学和更远的领域。坚定地植根于进化生物学 通过一种高度整合的方法，微生物种群中的GRC 生物学吸引了进化生物学、生态学、计算等领域的研究人员 生物学、分子生物学、医学微生物学和流行病学、细菌 遗传学、种群遗传学，以及最近的系统生物学。研究 在这个快速增长的领域的前沿是始终如一的创新(高 在顶级期刊发表有影响力的论文是常态)。这项申请寻求资金 支持在2007年举行的关于传染病演变的特别会议 微生物种群生物学GRC会议。 新的传染病(包括抗生素)的出现 抵抗)是现实。近年来出现了艾滋病毒、SARS 世界仍然敏锐地意识到一种新流感的可能性 大流行。虽然对疾病的研究通常属于 临床医生和微生物学家认为，新的传染病是 主要是进化论和生态学方面的问题。分子生物学可能会告诉我们 需要多少突变才能从H5N1(禽流感)转变为 可以在人类群体中传播，但进化生物学 询问这些突变的来源，它们需要的顺序 发生和发生的可能性：从这一点就有可能 建立模型并做出预测。 在了解传染病的出现方面取得了实际进展 而抗生素耐药性(包括其控制)需要医生谈论 与进化生物学家对话；理论家与实验主义者对话。我们 提议将不同领域的科学家聚集在一起，以便专注于 最前沿的问题。随之而来的思想交流？尤其是当 由所有与会者之间的公开辩论推动的？将要 促使出现新的概念和方法来研究 传染病的出现，最终会对什么产生影响 可以说是我们这个时代最重要的公共卫生问题。

Microbial population biology covers a diverse range of cutting edge issues in the microbial sciences and beyond. Firmly founded in evolutionary biology and with a strongly integrative approach, the GRC in Microbial Population Biology attracts researchers from evolutionary biology, ecology, computational biology, molecular biology, medical microbiology and epidemiology, bacterial genetics, population genetics, and more recently, systems biology. Research at the cutting edge of this rapidly growing field is consistently innovative (high impact papers in the top journals is the norm). This application seeks funding to support a special session on the evolution of infectious disease at the 2007 meeting of the Microbial Population Biology GRC. The emergence of new kinds of infectious disease (including antibiotic resistance) is a reality. Recent years have seen the emergence of HIV, SARS and the world remains acutely aware of the possibility of a new influenza pandemic. While the study of diseases typically falls within the domain of clinicians and microbiologists, the emergence of new infectious disease is primarily a problem in evolution and ecology. Molecular biology might tell us how many mutations are needed to switch from H5N1 (bird flu) to a form that is transmissible through human populations, but it is evolutionary biology that asks about the origin of these mutations, the order in which they need to occur and the likelihood of their occurrence: from this it becomes possible to build models and make predictions. Real progress in understanding the emergence of infectious disease and antibiotic resistance (including its control) requires that physicians talk with evolutionary biologists; that theorists talk with experimentalists. We propose to bring together a diverse spectrum of scientists in order to focus on cutting edge issues. The ensuing exchange of ideas ? particularly when fuelled by open debate among the full spectrum of meeting participants ? will provoke the emergence of new concepts and approaches for the study of the emergence of infectious disease that will ultimately make a difference to what is arguably the most significant public health issue of our time.