2009 Microbial Population

2009 年微生物种群

• 批准号: 7743611
• 负责人: Antony M. DEAN
• 金额: $ 1.52万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-13 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7743611
• 关键词: Antibiotic Resistance; Avian Influenza; Biology; Communicable Diseases; Computational Biology; Disease; Ecology; Epidemiologist; Epidemiology; Evolution; Funding; HIV; Human; Infection; Influenza A Virus, H5N1 Subtype; Journals; Medical Microbiology; Modeling; Molecular; Molecular Biology; Mutation; Paper; Participant; Physicians; Population; Population Biology; Population Genetics; Public Health; Research; Research Personnel; Science; Scientist; Severe Acute Respiratory Syndrome; Systems Biology; Time; bacterial genetics; base; falls; infancy; infectious disease evolution; innovation; meetings; microbial; pandemic influenza

DESCRIPTION (provided by applicant): Microbial population biology covers a diverse range of cutting edge issues in the microbial sciences and beyond. Firmly founded in evolutionary biology and with a strongly integrative approach, the GRC in Microbial Population Biology attracts researchers from evolutionary biology, ecology, computational biology, molecular biology, medical microbiology and epidemiology, bacterial genetics, population genetics, and more recently, systems biology. Research at the cutting edge of this rapidly growing field is consistently innovative (high impact papers in the top journals is the norm). This application seeks funding to support a special session on the evolution of infectious disease at the 2009 meeting of the Microbial Population Biology GRC. The emergence of new kinds of infectious disease (including antibiotic resistance) is a reality. Recent years have seen the emergence of HIV, SARS and the world remains acutely aware of the possibility of a new influenza pandemic. While the study of diseases typically falls within the domain of clinicians and microbiologists, the emergence of new infectious disease is primarily a problem in evolution and ecology. Molecular biology might tell us how many mutations are needed to switch from H5N1 (bird flu) to a form that is transmissible through human populations, but it is evolutionary biology that asks about the origin of these mutations, the order in which they need to occur and the likelihood of their occurrence: from this it becomes possible to build models and make predictions. Real progress in understanding the emergence of infectious disease and antibiotic resistance (including its control) requires that physicians talk with evolutionary biologists; that theorists talk with experimentalists. We propose to bring together a diverse spectrum of scientists in order to focus on cutting edge issues. The ensuing exchange of ideas - particularly when fuelled by open debate among the full spectrum of meeting participants - will provoke the emergence of new concepts and approaches for the study of the emergence of infectious disease that will ultimately make a difference to what is arguably the most significant public health issue of our time.

描述（由申请人提供）：微生物种群生物学涵盖了微生物科学及其他领域的各种前沿问题。微生物群体生物学GRC牢固地建立在进化生物学基础上，并采用强有力的综合方法，吸引了来自进化生物学、生态学、计算生物学、分子生物学、医学微生物学和流行病学、细菌遗传学、群体遗传学以及最近的系统生物学的研究人员。这个快速发展领域的前沿研究始终具有创新性（顶级期刊上发表高影响力的论文是常态）。本申请寻求资金支持 2009 年微生物种群生物学 GRC 会议上关于传染病演变的特别会议。新型传染病（包括抗生素耐药性）的出现已成为现实。近年来，艾滋病毒、非典的出现，世界仍然敏锐地意识到新的流感大流行的可能性。虽然疾病的研究通常属于临床医生和微生物学家的领域，但新传染病的出现主要是进化和生态学的问题。分子生物学可能会告诉我们需要多少突变才能从 H5N1（禽流感）转变为可在人群中传播的形式，但进化生物学需要了解这些突变的起源、它们发生的顺序以及发生的可能性：由此可以建立模型并进行预测。在了解传染病和抗生素耐药性（包括其控制）的出现方面取得真正的进展需要医生与进化生物学家进行交谈；理论家与实验家交谈。我们建议汇集不同领域的科学家，以专注于前沿问题。随后的思想交流——特别是在所有会议参与者之间的公开辩论的推动下——将引发研究传染病出现的新概念和方法的出现，这将最终对我们这个时代最重要的公共卫生问题产生影响。