2007 SALIVARY GLANDS & EXOCRINE SECRETION GORDON RESEARCH CONFERENCE

描述（由申请人提供）：本申请为将于2007年2月11日至16日在加州文图拉港镇福点喜来登酒店举行的第六届戈登唾液腺和外分泌研究会议寻求支持。会议将提供一个论坛，介绍和广泛讨论了解唾液腺和相关外分泌腺的发育，功能和功能障碍的分子基础的最新进展。本次会议的主题是腺体组织的正常和疾病状态。个别会议将重点介绍腺体形态发生和维持背后的分子和细胞相互作用的新见解；蛋白质、液体和电解质的分泌；累及上皮的自身免疫性疾病；细胞内信号的空间组织与极化膜运输利用唾液作为诊断工具，并在临床上观察到炎症和腺体功能障碍。主题演讲将邀请具有国际地位的知名研究人员，他们将围绕唾液腺发育和细胞死亡的应用以及探索水运中的信号网络等领域的一般主题（约翰·杨纪念演讲）。在组织这次会议的过程中，广泛的国内和国际演讲者已被确定，其中包括有前途的年轻和新成立的研究人员，他们的研究要么涉及或明显影响对唾液腺和其他外分泌腺的发育和功能的理解。组织团队的目标是鼓励这一重要领域的发展和丰富，并激发研究唾液腺的新策略。唾液功能障碍和外阴疾病（包括格林综合征）是口腔健康和生活质量的重要问题。临床上，患有唾液腺功能障碍（唾液流量减少）的个体有吞咽困难，患龋齿和口腔真菌感染的风险增加，以及味觉改变。唾液腺和其他外阴腺被作为模型系统来探索信号事件与分泌开始之间的耦合。

DESCRIPTION (provided by applicant): This application seeks support for the sixth Gordon Research Conference on Salivary Glands and Exocrine Secretion to be held February 11-16, 2007 at the Four Points Sheraton Harbortown in Ventura, California. The conference will provide a forum for presentation and extensive discussion of the most recent progress in understanding the molecular basis of development, function and dysfunction of salivary and related exocrine glands. The general theme of this conference is normal and disease states of glandular tissues. Individual sessions will highlight new insights concerning molecular and cellular interactions underlying the glandular morphogenesis and maintenance; protein, fluid and electrolyte secretion; autoimmune diseases involving epithelia; spatial organization of intracellular signaling and polarized membrane trafficking; use of saliva as a diagnostic tool, and clinically observed inflammation and glandular dysfunction. Keynote addresses will feature established investigators of international stature who encompass the general theme in the areas of the application of salivary gland development and cell death, and signaling networks in exploring water transport (The John Young Memorial Lecture). In organizing this conference a broad range of national and international speakers has been identified with the inclusion of promising young and newly established investigators whose research either addresses or clearly impacts on the understanding of the development and function of salivary and other exocrine glands. It is the goal of the organizing team to encourage both growth and enrichment of this important field and to stimulate new strategies for studying salivary glands. Salivary dysfunction and exocrinal diseases (including Sj"gren's syndrome) present significant oral health concerns as well as quality of life issues. Clinically, individuals experiencing salivary glands dysfunction (reduced salivary flow rate) have difficulty in swallowing, increased risks of dental caries and oral fungal infections, and alterations in taste. Salivary and other exocrinal glands have served as a model system to explore the coupling between signaling events and initiation of secretion.