Clinical Relevance of Mismatch Repair in Ovarian Cancer

描述（由申请人提供）：一个为期5年的计划，整合研究，教育和教学将为申请人提供一个极好的机会，获得和完善研究方法的技能，包括设计，进行和分析高质量的流行病学为基础的癌症遗传学研究，在该领域科学家的专家指导下。重点教学培训的具体领域将是：1）遗传流行病学，2）研究设计和统计方法，3）基于实验室的分子分析，以及4）卵巢肿瘤生物学，目的是将这些知识应用于转化研究。培训和研究目标将通过正式培训（课程工作），导师（通过遗传流行病学，统计学，分子遗传学和卵巢肿瘤发生方面的专家导师/顾问）和实践经验（通过进行拟议的研究）来实现。这个特别的项目将通过分子，病理和统计分析的各个组成部分解决申请人的所有学习目标，并将为她提供在这些特定领域概述的实践经验。通过提供有意义的科学数据，该项目本身将增加与实验室标记物卵巢癌易感性遗传学相关的现有研究。它将建立在目前的知识，在破译病因和预测预后和治疗反应，因为它涉及到卵巢肿瘤发生的错配修复途径，并形成进一步的转化研究的基础。博士的长期目标是利用跨学科的方法开发一个基于流行病学的癌症遗传学研究计划。这一目标将通过在学术健康科学中心的教师角色来实现。赞助机构的资源是极好的，将有助于成功、有效地完成概述的总体目标。这些目标的实现将提供职业生涯所需的专业知识，作为一个成功的，独立的调查致力于学术研究。

DESCRIPTION (provided by applicant): A 5-year program integrating research, education, and teaching will provide the applicant with an excellent opportunity for the acquisition and refinement of skills in research methods that include design, conduct and analysis of high-quality epidemiologically-based cancer genetics research, under expert guidance of scientists in the field. Specific areas of focus for didactic training will be: 1) genetic epidemiology, 2) study design and statistical methodology, 3) laboratory-based molecular analyses, and 4) ovarian tumor biology, with the goal of applying this knowledge in translational research. The training and research objectives will be accomplished through formal training (course work), mentorship (through mentors/consultants who are experts in genetic epidemiology, statistics, molecular genetics and ovarian tumorigenesis), and practical experience (through conducting proposed research study). This particular project will address all learning objectives of the applicant through the various components of molecular, pathological and statistical analyses, and will provide her with the practical experience in these specific areas outlined. Through the provision of meaningful scientific data, the project itself will augment existing research associated with the genetics of ovarian cancer susceptibility with laboratory markers. It will build upon current knowledge in deciphering etiology and predicting prognosis and treatment response as it relates to the mismatch repair pathway to ovarian tumorigenesis, and form the basis of further translational studies. Dr. Pal's long-term goal is to develop a program of research in epidemiologically-based cancer genetics research utilizing an interdisciplinary approach. This goal will be accomplished by being in a faculty role at an academic health science center. The resources of the sponsoring institution are excellent and will facilitate the successful, efficient completion of the overall objectives outlined. The achievement of these goals will provide the expertise needed for a career as a successful, independent investigator committed to academic research.