Clinical Relevance of Mismatch Repair in Ovarian Cancer

卵巢癌错配修复的临床意义

• 批准号: 7919385
• 负责人: Tuya Pal
• 金额: $ 13.28万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919385
• 关键词: Achievement; Address; Age; Area; Cancer Center; Cancer Patient; Cessation of life; Characteristics; Clinical; Colorectal Cancer; Commit; Communities; Complex; Data; Diagnosis; Diagnostic; Disease; Education; Educational process of instructing; Epidemiology; Epigenetic Process; Epithelial ovarian cancer; Etiology; Faculty; Family Cancer History; Family history of; Functional disorder; Gene Mutation; Genes; Genetic; Genetic Research; Germ-Line Mutation; Goals; Health Sciences; Hereditary Nonpolyposis Colorectal Neoplasms; Histology; Hormonal Risk Factor; Hypermethylation; Incidence; Inherited; Institution; Investigation; Knowledge; Laboratories; Laboratory Markers; Learning; MLH1 gene; MSH2 gene; MSH6 gene; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Mayo Clinic Cancer Center; Medical Records; Mentors; Mentorship; Methodology; Methylation; Microsatellite Instability; Microsatellite Repeats; Mismatch Repair; Modeling; Molecular; Molecular Genetics; Mutation; Mutation Analysis; Nature; Ovarian; Pathogenesis; Pathway interactions; Patients; Postdoctoral Fellow; Predictive Factor; Predisposition; Prevalence; Prognostic Marker; Proteins; Questionnaires; Research; Research Design; Research Methodology; Research Personnel; Research Training; Resources; Risk Factors; Role; Sampling; Scientist; Stage at Diagnosis; Syndrome; Testing; Therapeutic; Training; Translating; Translational Research; Tumor Biology; United States; Woman; Work; base; cancer genetics; career; clinically relevant; design; experience; follow-up; genetic epidemiology; improved; interdisciplinary approach; mortality; outcome forecast; ovarian neoplasm; prognostic; programs; promoter; protein expression; research study; response; skills; statistics; tool; translational study; treatment response; tumor; tumorigenesis

A 5-year program integrating research, education, and teaching will provide the applicant with an excellent opportunity for the acquisition and refinement of skills in research methods that include design, conduct and analysis of high-quality epidemiologically-based cancer genetics research, under expert guidance of scientists in the field. Specific areas of focus for didactic training will be: 1) genetic epidemiology, 2) study design and statistical methodology, 3) laboratory-based molecular analyses, and 4) ovarian tumor biology, with the goal of applying this knowledge in translational research. The training and research objectives will be accomplished through formal training (course work), mentorship (through mentors/consultants who are experts in genetic epidemiology, statistics, molecular genetics and ovarian tumorigenesis), and practical experience (through conducting proposed research study). This particular project will address all learning objectives of the applicant through the various components of molecular, pathological and statistical analyses, and will provide her with the practical experience in these specific areas outlined. Through the provision of meaningful scientific data, the project itself will augment existing research associated with the genetics of ovarian cancer susceptibility with laboratory markers. It will build upon current knowledge in deciphering etiology and predicting prognosis and treatment response as it relates to the mismatch repair pathway to ovarian tumorigenesis, and form the basis of further translational studies. Dr. Pal's long-term goal is to develop a program of research in epidemiologically-based cancer genetics research utilizing an interdisciplinary approach. This goal will be accomplished by being in a faculty role at an academic health science center. The resources of the sponsoring institution are excellent and will facilitate the successful, efficient completion of the overall objectives outlined. The achievement of these goals will provide the expertise needed for a career as a successful, independent investigator committed to academic research.

一个集研究，教育和教学于一体的5年计划将为申请人提供一个优秀的 获得和完善研究方法技能的机会，包括设计，进行和 在专家指导下，分析高质量的基于流行病学的癌症遗传学研究， 科学家在现场。教学培训的具体重点领域将是：1）遗传流行病学，2）研究 设计和统计方法学，3）基于实验室的分子分析，和4）卵巢肿瘤生物学， 目的是将这些知识应用于翻译研究。培训和研究目标将 通过正规培训（课程工作）、导师制（通过 遗传流行病学、统计学、分子遗传学和卵巢肿瘤发生方面的专家）， 经验（通过开展拟议的研究）。这个特别的项目将解决所有学习 申请人的目标是通过分子、病理和统计学的各个组成部分 分析，并将向她提供这些具体领域的实际经验。通过 提供有意义的科学数据，该项目本身将加强与 卵巢癌易感性的遗传学与实验室标志物。它将建立在现有知识的基础上， 解释病因并预测预后和治疗反应，因为它与错配修复有关。 卵巢肿瘤发生的途径，并形成进一步的翻译研究的基础。长期以来， 目标是开发一个基于流行病学的癌症遗传学研究项目， 跨学科方法。这一目标将通过在学术健康的教师角色来实现 科学中心。主办机构的资源是优秀的，将促进成功的， 高效率地完成总体目标。这些目标的实现将提供 专业知识需要作为一个成功的职业生涯，独立的调查致力于学术研究。