Epidemiologic Studies of Alcohol Use Disorders (ongoing)

酒精使用障碍的流行病学研究（正在进行）

• 批准号: 7487721
• 负责人: DEBORAH S HASIN
• 金额: $ 2.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7487721
• 关键词: Address; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Area; Dependence; Development; Disease; Doctor of Philosophy; Drug Use Disorder; Educational process of instructing; Environment; Epidemiologic Studies; Epidemiology; Exposure to; Future; General Population; Genes; HIV; Immigrant; International; Intervention; Israel; Leadership; Major Depressive Disorder; Mentors; Natural History; Patients; Physicians; Population; Primary Health Care; Productivity; Psychiatry; Public Health; Public Health Schools; Purpose; Research; Research Scientist Award; Role; Scientific Advances and Accomplishments; Senior Scientist Award; Severities; Subgroup; Surgeon; Universities; Work; alcohol use disorder; college; concept; drinking; early /brief intervention /therapy; gene environment interaction; programs; science education

Alcohol abuse and dependence are significant public health problems in the U.S. and worldwide. Clarifying the causes for onset and chronicity of these problems is a high scientific priority, as is the development of practical, effective interventions. This is an application fbr a K05 Research Scientist Award for Deborah Hasin, Ph.D. The purpose is to provide 5 years of ongoing support for Dr. Hasin to continue and expand her leadership role in alcoholism research. This will be achieved through the K05 release from teaching and administrative duties, allowing Dr. Hasin to continue to concentrate on her research and mentoring, which is characterized by a very high level of scientific accomplishment and productivity. During the K05 award, Dr. Hasin proposes to continue her research program at Columbia University (Mailman School of Public Health, Department of Epidemiology and College of Physicians and Surgeons, Department of Psychiatry). Dr. Hasin's research has focused on four main areas. (1) The validity of concepts of alcohol use disorders in the general population and the natural history of those disorders. (2) The relationship of major depression to alcohol and drug use disorders. Dr. Hasin's work has answered some of the main questions in these two areas, and continues to address important remaining issues. (3) Gene-environment interaction. Israeli population subgroups differ in their exposures to drinking environments and in their drinking. By studying alcohol metabolizing genes, alcohol consumption, and dependence severity in recent Russian immigrants to Israel and other Israelis, Dr. Hasin has identified a unique opportunity to study specific genes under sharply contrasting environmental circumstances (background per capita alcohol consumption levels). Dr. Hasin's work in this area has been described as critical for future directions in gene-environment studies of alcohol. Dr. Hasin will also continue to develop a newer area. (4) Brief intervention for unsafe drinking among patients in HIV primary care. Dr. Hasin will conduct her multifaceted program of research with experts at Columbia University and elsewhere. The K05 plan also includes continued participation in national and international scientific activities, and expansion of Dr. Hasin's mentoring and science education. By releasing Dr. Hasin from other responsibilities, the K05 award will allow Dr. Hasin to maintain her outstanding level of contribution to the field of alcoholism research.

酗酒和依赖是美国和世界范围内严重的公共卫生问题。 弄清这些问题的起因和长期性是一个高度科学的优先事项，发展也是如此 切实有效的干预措施。这是为黛博拉·哈辛颁发的K05研究科学家奖， 博士。目的是为哈辛博士提供5年的持续支持，以继续和扩大她的领导能力 在酒精中毒研究中的作用。这将通过K05版本从教学和管理中实现 职责，让哈辛博士继续专注于她的研究和指导，这是一个 非常高的科学素养和生产力。在K05奖项期间，哈辛博士提议 继续她在哥伦比亚大学的研究项目(梅尔曼公共卫生学院 流行病学和内科和外科医学院，精神病学系)。哈辛博士的研究已经 重点关注四个主要领域。(1)酒精使用障碍概念在普通人群中的有效性 这些疾病的自然病史。(2)重度抑郁症与酒精、药物使用障碍的关系。Dr。 哈辛的工作回答了这两个领域的一些主要问题，并继续解决重要的 遗留问题。(3)基因-环境互作。以色列人口亚群在暴露于 在饮酒环境和他们的饮酒中。通过研究酒精代谢基因、酒精摄入量和 在最近到以色列和其他以色列人的俄罗斯移民中，哈辛博士发现了一个独特的 在截然不同的环境环境下研究特定基因的机会(人均背景 酒精消费水平)。哈辛博士在这一领域的工作被描述为对未来的方向至关重要 酒精的基因环境研究。哈辛博士还将继续开发一个新的领域。(4)短暂干预 在艾滋病毒初级保健中的患者中不安全饮酒。哈辛博士将进行她的多方面计划 与哥伦比亚大学和其他地方的专家进行了研究。K05计划还包括继续参与 参与国家和国际科学活动，并扩大哈辛博士的指导和科学教育。 通过解除哈辛博士的其他责任，K05奖将允许哈辛博士保持她的杰出表现 对酒精中毒研究领域的贡献水平。