Short Course on Integrative Modeling of the Cardiac Myocyte

描述(由申请人提供)： 短期课程“心肌细胞的综合模型”将培训生物医学研究人员和临床医生科学家如何开发和应用以生物物理和生物化学为基础的详细的、基于实验的心肌细胞计算模型。重点是利用实验数据进行模型的模块化开发和测试、求解模型方程的数值方法、开发和求解单元的多尺度模型的数学技术以及分析模型的参数敏感性的方法。这门课程的方法是由哈里·戈德堡博士开发的，并被广泛纳入JHU医学院的课程。在这种方法中，开发光盘和/或基于网络的学习模块，并在讲课前提供给学生。这些学习模块提供了每堂课的核心材料。然后，讲座被用作与学生直接互动的机会，解决关于核心材料的问题，并应用或更深入地研究核心材料。这些学习模块将使用Macromedia Breeze开发，并将通过网络向每个人提供。将编写关于如何创建新的学习模块的教学材料，从而使心血管研究界能够下载现有的学习模块，并生成他们自己设计的新的学习模块，这些模块可以添加到他们的网络课程实例化中，以满足当地的教育需求。

DESCRIPTION (provided by applicant): The short course "Integrative Models of the Cardiac Myocyte" will train biomedical researchers and clinician-scientists in how to develop and apply biophysically- and biochemically-detailed, experimentally-based computational models of the cardiac myocyte. Emphasis will be on modular development and testing of models using experimental data, numerical methods for solving model equations, mathematical techniques for developing and solving multi-scale models of the cell and methods for analyzing parameter sensitivity of models. The approach to this course is that developed by Dr. Harry Goldberg and which is being incorporated extensively into the JHU School of Medicine curriculum. In this approach, cd-rom and/or web-based learning modules are developed and provided to students prior to lecture. These learning modules present the core material for each lecture. Lectures are then used as an opportunity for direct interaction with students, to address questions on the core material and to apply or delve more deeply into the core material. These learning modules will be developed using Macromedia Breeze and will be available to everyone via the web. Instructional materials on how to create new learning modules will be created, thus enabling the cardiovascular research community to download existing learning modules, and generate new learning modules of their own design which may be added to their instantiation of the web course in order to meet local educational needs.