Depressive Symptoms, Aging, Disability and Health Outcomes

抑郁症状、衰老、残疾和健康结果

基本信息

项目摘要

DESCRIPTION (provided by applicant): Difficulty with basic tasks such as activities of daily activities (ADL) or walking a short distance are relatively uncommon in middle life but become increasingly common as people age, often leading to disability. While these disabilities may not become apparent until people enter old age, they likely have their antecedents in risk factors that develop in middle life. Understanding midlife determinants of later life disability is of major public health importance because these disabilities severely compromise the quality of life of older persons and are risk factors for other adverse outcomes such as the need for caregiver assistance, nursing home placement, and death. There is a strong rationale for hypothesizing that mid-life depressive symptoms are an important risk factor for later life disability and related outcomes. Middle age people with depressive symptoms are more likely to have work-related disability and depression in late life is associated with concurrent and future ADL impairment. It is largely unknown, however, whether middle age persons with depressive symptoms are at higher risk for the common disabilities of later life and the consequences of disability. Understanding these relationships is important because depression is common and a potentially modifiable risk factor. We propose to make innovative use of the prospective, population-based Health and Retirement Study (MRS) to examine the impact of midlife depressive symptoms on later life disability and related health outcomes. We will follow 9286 subjects who were age 51-61 when enrolled in 1992 and will range in age from 67-77 by 2008. Depressive symptoms were assessed at enrollment (CES-D) and disability outcomes (such as ADL and walking difficulty) and other health outcomes are assessed every 2 years. Our aims are to (1) examine the relationship between mid-life depressive symptoms and later life disability; (2) examine whether this relationship differs depending upon demographic and clinical factors, (3) examine whether depressive symptoms are associated with common consequences of disability such as need for caregiver assistance, nursing home placement and death; (4) examine whether depressive symptoms are associated with early retirement and whether early retirement identifies subjects at particularly high risk for later life disability. This study will have unique public health importance because it will be one of the longest outcome studies comprehensively assessing the long term impact of depressive symptoms as subjects progress from middle life to later life. This has important implications for life course interventions to prevent older age disability as it will provide insight into whether it is plausible that better recognition and management of depression in mid life might improves outcomes in later life.
描述(由申请人提供):日常活动(ADL)或短距离步行等基本任务困难在中年相对较少见,但随着年龄的增长变得越来越常见,通常会导致残疾。虽然这些残疾可能在人们进入老年之前不会变得明显,但他们很可能在中年形成的风险因素中有先兆。了解晚年残疾的中年决定因素具有重大的公共卫生意义,因为这些残疾严重损害老年人的生活质量,并是其他不良后果的风险因素,如需要照顾者援助、养老院安置和死亡。有一个强有力的理由假设,中年抑郁症状是晚年残疾和相关后果的重要风险因素。有抑郁症状的中年人更有可能患有与工作相关的残疾,晚年抑郁与并发和未来的ADL损害有关。然而,有抑郁症状的中年人是否有更高的风险患上晚年常见的残疾和残疾的后果,在很大程度上是未知的。了解这些关系很重要,因为抑郁症很常见,而且是一个潜在的可改变的风险因素。我们建议创新地利用基于人群的前瞻性健康和退休研究(MRS)来检查中年抑郁症状对晚年残疾和相关健康结果的影响。我们将跟踪9286名受试者,他们在1992年登记时年龄在51-61岁之间,到2008年将在67-77岁之间。在登记时评估抑郁症状(CES-D),每两年评估一次残疾结果(如ADL和行走困难)和其他健康结果。我们的目标是(1)研究中年抑郁症状与晚年残疾之间的关系;(2)检验这种关系是否因人口和临床因素而异;(3)检验抑郁症状是否与残疾的常见后果有关,例如需要照顾者的帮助、养老院安置和死亡;(4)检验抑郁症状是否与提前退休有关,以及提前退休是否识别出日后残疾风险特别高的对象。这项研究将具有独特的公共卫生重要性,因为它将是最长的结果研究之一,全面评估受试者从中年到晚年抑郁症状的长期影响。这对预防老年残疾的生命过程干预具有重要意义,因为它将提供关于中年更好地认识和管理抑郁症是否可能改善晚年生活结果的洞察。

项目成果

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KENNETH E. COVINSKY其他文献

KENNETH E. COVINSKY的其他文献

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{{ truncateString('KENNETH E. COVINSKY', 18)}}的其他基金

DEploying High ValuE LOngitudinal Population-Based dAta in Dementia Research (DEVELOP AD Research)
在痴呆症研究中部署基于人群的高价值纵向数据(DEVELOP AD 研究)
  • 批准号:
    10689035
  • 财政年份:
    2020
  • 资助金额:
    $ 31.7万
  • 项目类别:
DEploying High ValuE LOngitudinal Population-Based dAta in Dementia Research (DEVELOP AD Research)
在痴呆症研究中部署基于人群的高价值纵向数据(DEVELOP AD 研究)
  • 批准号:
    10615460
  • 财政年份:
    2020
  • 资助金额:
    $ 31.7万
  • 项目类别:
DEploying High ValuE LOngitudinal Population-Based dAta in Dementia Research (DEVELOP AD Research)
在痴呆症研究中部署基于人群的高价值纵向数据(DEVELOP AD 研究)
  • 批准号:
    10265431
  • 财政年份:
    2020
  • 资助金额:
    $ 31.7万
  • 项目类别:
UCSF Older Americans Independence Center
加州大学旧金山分校美国老年人独立中心
  • 批准号:
    10119175
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:
UCSF Older Americans Independence Center
加州大学旧金山分校美国老年人独立中心
  • 批准号:
    8920983
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:
UCSF Older Americans Independence Center
加州大学旧金山分校美国老年人独立中心
  • 批准号:
    8910596
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:
UCSF Older Americans Independence Center
加州大学旧金山分校美国老年人独立中心
  • 批准号:
    10198655
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:
LAC Admin
拉克管理员
  • 批准号:
    10198656
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:
LAC Admin
拉克管理员
  • 批准号:
    10434051
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:
UCSF Older Americans Independence Center
加州大学旧金山分校美国老年人独立中心
  • 批准号:
    10729111
  • 财政年份:
    2013
  • 资助金额:
    $ 31.7万
  • 项目类别:

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    2021
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Reducing Hypertension among African American Men: A Mobile Stress Management Intervention to Address Health Disparities
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    10245326
  • 财政年份:
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Building a Multidisciplinary Research Program to Address Hypertension Disparities:Exploring the Neurocognitive Mechanisms of a Self-Management Intervention for African American Women with Hypertension
建立一个多学科研究计划来解决高血压差异:探索非裔美国高血压女性自我管理干预的神经认知机制
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    10334538
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