Genome engineered, preclinical models of serrated colorectal cancer to fast-track a high sensitivity, early detection test

每12个澳大利亚人中就有1个会患上结直肠癌。在这里，我们使用这些癌症的遗传（遗传）物质变化的信息来开发这种疾病的新的复杂模型。这告诉我们这些变化的作用，并强调了未来药物治疗的重要目标。我们还在开发一种更好的检测方法，以检测我们目前的人口筛查策略无法很好检测到的隐藏的癌前病变，以帮助减少这种疾病的死亡。

1 in 12 Australians will develop colorectal cancer. Here we use information about changes to the genetic (inherited) material of these cancers to develop new, complex models of this disease. This teaches us about what those changes do, and highlights important targets for future drug therapies. We are also developing a better test to detect hidden pre-cancers that are not well detected by our current population screening strategy, to help reduce deaths from this disease.