Genome engineered, preclinical models of serrated colorectal cancer to fast-track a high sensitivity, early detection test

锯齿状结直肠癌的基因组工程临床前模型可快速进行高灵敏度、早期检测测试

• 批准号: nhmrc : GNT1140236
• 负责人: Dr Susan Woods
• 金额: $ 59.39万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genome-engineered-preclinical-detection-test/1348291
• 关键词: Genome; engineered; preclinical; models; serrated

1 in 12 Australians will develop colorectal cancer. Here we use information about changes to the genetic (inherited) material of these cancers to develop new, complex models of this disease. This teaches us about what those changes do, and highlights important targets for future drug therapies. We are also developing a better test to detect hidden pre-cancers that are not well detected by our current population screening strategy, to help reduce deaths from this disease.

每12个澳大利亚人中就有1人会患结直肠癌。在这里，我们利用这些癌症的遗传物质变化的信息来开发这种疾病的新的、复杂的模型。这让我们了解了这些变化的作用，并强调了未来药物治疗的重要目标。我们还在开发一种更好的检测方法，以检测我们目前的人口筛查策略无法很好地检测到的隐藏的癌前病变，以帮助减少这种疾病的死亡。