Genome-wide association studies to identify major genetic determinants of 5 blinding eye diseases using pooled DNA

全基因组关联研究利用混合 DNA 确定 5 种致盲性眼病的主要遗传决定因素

• 批准号: nhmrc : 1031362
• 负责人: A/Pr Alex Hewitt
• 金额: $ 37.49万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genome-wide-association-pooled-dna/110804
• 关键词: Genome; wide; association; studies; identify

This project aims to find important genes for 5 diseases that can lead to blindness. We will use a cost-effective approach where samples from a large number of individuals with a given disorder are pooled (mixed together) and then compared on gene chips covering the whole genome to a pool of people who do not have the disease. Differences identified between the groups will point to genes causing that disease. We will identify any major genes for the 5 diseases being studied.

该项目旨在寻找5种可能导致失明的疾病的重要基因。我们将使用一种具有成本效益的方法，将大量患有某种疾病的人的样本汇集(混合在一起)，然后在覆盖整个基因组的基因芯片上与一群没有患这种疾病的人进行比较。两组之间发现的差异将指向导致这种疾病的基因。我们将确定正在研究的5种疾病的任何主要基因。