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Pulmonary Pathogen Defense Mechanisms

肺部病原体防御机制

基本信息

批准号：
7504135
负责人：
W. Henry Boom
金额：
$ 5.41万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-07-01 至 2008-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7504135
关键词：
Defense Mechanisms Lung pathogen

项目摘要

Thiscompetitirvenewalpplicatiofonrapostdoctotrralininpgrograminpulmonahryostdefensetosmicrobial pathogen(HsL-0788a9t)CaseWesterRneservUeniversi(tCy WRUs)eeksrenewaful ndinfgoraresearcthraining programforM.D.M, .D.-Ph.Dan. dPh.Ds.cientistsF.undinfgorthisnovetlrainingprogramwasawardeidn7/199o8n thestrengtohftheresearcphrogramastCWRUinprogrammatriceasoftuberculosHisI,Vandcomplicationfscystic fibrosisR. esearcinhpulmonahryostdefenseastCWRUhasremaineadn institutional strength, with internationally recognized faculty with research programs on major pulmonary pathogens such as M. tuberculosis, HIV-1, Streptococcus pneumonia and Pseudomonas aeruginosa. Interdisciplinary approaches to study of host defenses to these bacterial and viral pulmonary pathogens involve faculty across basic and clinical departments and include immunology, molecular biology, biochemistry, genetics and cell biology. The interdisciplinary collaborations at CWRU in the area of pulmonary host defenses against microbial pathogens are greatly facilitated by the infrastructures of the Tuberculosis Research Unit (TBRU), the Center for AIDS Research (CFAR), the AIDS Clinical Trails Unit (ACTU), the Cystic Fibrosis Center and the NIH-funded Clinical Research Center (GCRC). In addition, strong basic research programs in the Departments of Pediatrics and Medicine in close proximity to and collaboration with clinical scientists has created a rich environment allowing trainees to learn how basic research translates into clinical investigation. The goals of the research training program are: 1. To provide rigorous training for promising M.D., M.D.-Ph.D. and Ph.D. postdoctoral fellows in the application of the tools of immunology, molecular biology or biochemistry to pulmonary host defenses to pathogens such as M. tuberculosis and HIV-I. 2. To assume an active role in career development by training and assisting trainees in securing funding either for additional postdoctoral training or for faculty development depending on their level of training at entree into the program and development in the training program.

这是竞争性的新应用，对博士后肺结核患者进行抗菌治疗病原体（HsL-0788 a9 t）病例Westernervueniversi（tCy WRU）研究进展医学博士的程序- Ph.Dan. 199 o 8年7月， CWRU在His-I、Vu及胆囊并发症程序化诊断中的应用纤维变性河EscharcinhpulmonahrystdefenseastCWRU拥有领先的机构实力，在国际上公认的教师与主要肺部病原体的研究计划，如M。肺结核、HIV-1、肺炎链球菌和绿脓杆菌。跨学科的方法来研究宿主防御，这些细菌和病毒性肺部病原体涉及基础和临床部门的教师，包括免疫学、分子生物学、生物化学、遗传学和细胞生物学。CWRU的跨学科合作在肺宿主对微生物病原体的防御方面，结核病研究单位（TBRU），艾滋病研究中心（CFAR），艾滋病临床试验单位（ACTU），囊性纤维化中心和NIH资助的临床研究中心（GCRC）。此外，强大的基础研究在儿科和医学系的项目，与临床科学家密切合作，创造了一个丰富的环境，让学员学习如何将基础研究转化为临床研究。的研究培训方案的目标是： 1.为有前途的医学博士提供严格的训练，医学博士-博士和博士博士后研究员在应用的免疫学、分子生物学或生物化学的工具来研究肺宿主对病原体如M. 结核病和艾滋病毒I。 2.在职业发展方面发挥积极作用，为学员提供培训，并协助学员获得以下方面的资助：额外的博士后培训或教师发展，这取决于他们在进入该计划的培训水平在培训计划中的发展。