Novel RF Coils for In Vivo MR Applications at High Field

适用于高场体内 MR 应用的新型射频线圈

• 批准号: 7216720
• 负责人: Wei Chen
• 金额: $ 46.5万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-10-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7216720
• 关键词: Address; Animals; Applications Grants; Basic Science; Behavior; Cell Nucleus; Collaborations; Communities; Complex; Computer Simulation; Condition; Detection; Development; Engineering; Facility Construction Funding Category; Financial compensation; Frequencies; Functional Magnetic Resonance Imaging; Goals; Head; Human; Image; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Medicine; Minnesota; Modeling; Noise; Operative Surgical Procedures; Outcome; Outcomes Research; Pennsylvania; Performance; Phase; Radiology Specialty; Range; Research; Series; Signal Transduction; Simulate; Solutions; Spatial Distribution; Spectrum Analysis; Structure; Surface; System; Universities; Validation; Yang; base; clinical Diagnosis; college; design; experience; human study; improved; in vivo; innovation; magnetic field; novel; radiofrequency; size; study characteristics; theories; transmission process

DESCRIPTION (provided by applicant): Technical developments in high-field magnetic resonance imaging (MRI) and spectroscopy (MRS) have been accelerated because of the advantage of high sensitivity that significantly improves the capability and reliability for human applications. This advancement is further stimulated by the unique image contrasts available at high fields for fMRI and clinical diagnosis. However, to fully realize the advancement, many challenges must be resolved. Major problems associated with high fields are the difficulty of radiofrequency (RF) coil designs and the complex magnetic fields (B1) of RF coil when the wavelength of RF wave approaches RF coil's size. They result in (i) severe degradation of coil quality factor and NMR sensitivity, (ii) limitation for designing large size coils with high operating frequency and (iii) complex B1 field distributions and difficulty for quantifying MRI intensity. These complications necessitate innovative strategies to overcome the problems associated with RF coils at high fields. In collaboration with Dr. Yang from Penn State University, a comprehensive project is proposed in this grant application for addressing the RF engineering challenges at high fields. The major goals will focus on (i) developing a host of robust and efficient high-field RF coils for human and animal studies using an innovative design based on the microstrip transmission line (MTL) approach, (ii) studying the B1 field behavior in human head at high fields using computer simulation based on RF field modeling and MRI measurements, and studying the implications of B1 field on MRI quantification, (iii) conducting a series of study for systematically evaluating the proposed coils in comparison with other existing coils. Successful outcomes from this research will provide an alternative and satisfactory solution of RF coil design at high fields and result in significant technological advances in high-field RF coil engineering for in vivo MR applications.

描述（由申请人提供）： 高场磁共振成像（MRI）和光谱学（MRS）的技术发展加速，因为其高灵敏度的优势显着提高了人类应用的能力和可靠性。用于功能磁共振成像和临床诊断的高场独特图像对比度进一步促进了这一进步。然而，要充分实现进步，必须解决许多挑战。与高场相关的主要问题是射频（RF）线圈设计的困难以及当射频波的波长接近射频线圈的尺寸时射频线圈的复杂磁场（B1）。它们导致 (i) 线圈品质因数和 NMR 灵敏度严重下降，(ii) 设计具有高工作频率的大尺寸线圈的限制，以及 (iii) 复杂的 B1 场分布和量化 MRI 强度的困难。这些复杂情况需要创新策略来克服与高场射频线圈相关的问题。在本次拨款申请中，与宾夕法尼亚州立大学的杨博士合作，提出了一个综合项目，用于解决高场射频工程挑战。主要目标将集中于（i）使用基于微带传输线（MTL）方法的创新设计，开发一系列坚固且高效的高场射频线圈，用于人类和动物研究，（ii）使用基于射频场建模和 MRI 测量的计算机模拟研究高场下人体头部的 B1 场行为，并研究 B1 场对 MRI 量化的影响，（iii）系统地进行一系列研究 与其他现有线圈进行比较，评估提议的线圈。这项研究的成功成果将为高场射频线圈设计提供替代且令人满意的解决方案，并为体内 MR 应用的高场射频线圈工程带来重大技术进步。