Nasal airflow and odorant transport: a prerequisite for normal olfaction

鼻气流和气味输送：正常嗅觉的先决条件

• 批准号: 7213902
• 负责人: KAI ZHAO
• 金额: $ 6.95万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-03 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213902
• 关键词: Accounting; Acoustic Rhinometry; Affect; Air; Anterior nares; Appendix; Area; Chemicals; Chronic; Clinic; Clinical; Clinical assessments; Condition; Constriction procedure; Deposition; Detection; Diagnosis; Disease; Epithelium; Esthesia; Future; Global Change; Goals; Human; Impairment; Individual; Inflammation; Intervention; Knowledge; Liquid substance; Location; Measurement; Measures; Mechanics; Medical; Modeling; Nasal Polyps; Nasal cavity; Nasal obstruction present finding; Nose; Numbers; Obstruction; Odors; Olfactory Epithelium; Operative Surgical Procedures; Outcome; Patients; Pattern; Process; Property; Psychometrics; Quantitative Evaluations; Range; Rate; Recovery; Regression Analysis; Reporting; Research; Research Personnel; Resistance; Resolution; Rhinomanometry; Sensory; Sinus; Site; Smell Perception; Solubility; Standards of Weights and Measures; Symptoms; Techniques; Testing; United States; Variant; X-Ray Computed Tomography; indexing; neuroepithelium; olfactory receptor; receptor; receptor function; rhinosinusitis; uptake

DESCRIPTION (provided by applicant): Mechanical obstruction of air/odorant flow to olfactory receptor sites may be a primary cause of olfactory loss in nasal-sinus disease patients. Unfortunately, quantifying the functional impact of various nasal obstruction and the subsequent surgical outcomes using acoustic rhinometry, rhinomanometry or CT scans is inadequate. Studies have shown a poor correlation between these existing objective measurements with patients' subjective symptoms. Recently developed computational fluid dynamic (CFD) modeling techniques have shown promise for quantifying the location-dependent, obstruction-induced changes in nasal airflow pattern and odorant mucosal deposition and have the potential to characterize their functional impact on patients' olfactory function. The goal of this application is to establish a baseline in nasal airflow pattern and odorant delivery rate among healthy subjects, from which the putative conductive mechanisms of olfactory loss among clinical patients can be verified in future. In the future, such modeling techniques may provide quantitative evaluation of surgical procedures and an important pre-operative guide to optimize airflow and odorant delivery in human nose.

描述（由申请人提供）：机械阻塞到嗅觉受体位点的空气/气味流量可能是鼻sinus病患者嗅觉损失的主要原因。不幸的是，使用声学隆隆法，隆手含量或CT扫描来量化各种鼻阻塞和随后的手术结果的功能影响不足。研究表明，这些现有的客观测量与患者的主观症状之间的相关性差。最近开发的计算流体动力学（CFD）建模技术已显示出有望量化位置依赖性的，阻塞诱导的鼻气流模式的变化和气味粘膜沉积的变化，并有可能表征其对患者嗅觉功能的功能影响。该应用的目的是在健康受试者中建立鼻气流模式和气味递送速度的基线，将来可以验证临床患者嗅觉损失的推定导电机制。将来，这种建模技术可能会对外科手术程序进行定量评估，并为优化人鼻中的气流和气味递送的重要术前指南提供定量评估。