Endoscopic nasal sinus surgery simulator to optimize treatment outcome

内窥镜鼻窦手术模拟器可优化治疗效果

• 批准号: 9884609
• 负责人: KAI ZHAO
• 金额: $ 19.69万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-05 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9884609
• 关键词: 3-Dimensional; Adult; Advanced Development; Affect; Aftercare; Air; Air Movements; Anatomy; Blinded; Clinical; Complex; Computers; Databases; Detection; Devices; Disease; Disease Management; Double-Blind Method; Drops; Endoscopy; Engineering; Enrollment; Etiology; Excision; Feedback; Fossa; Future; Hypertrophy; Intervention Studies; Lead; Liquid substance; Medical; Modeling; Nasal Polyps; Nasal turbinate bone structure; Nose; Obstruction; Odors; Operative Surgical Procedures; Outcome; Pathology; Patients; Polyps; Positioning Attribute; Preparation; Process; Research; Resistance; Scientist; Series; Sinus; Site; Smell Perception; Subgroup; Surgeon; Surgical Instruments; Symptoms; System; Tactile; Testing; Time; Tissues; Treatment outcome; Validation; Visual; Visualization; X-Ray Computed Tomography; base; clinical care; clinical practice; computer science; design; functional improvement; functional outcomes; haptics; image guided; image processing; improved; improved outcome; innovation; multidisciplinary; nasal obstruction; particle; personalized medicine; preservation; pressure; prospective; prototype; shear stress; surgery outcome; tool; treatment optimization; virtual; virtual reality; virtual reality system; virtual surgery

Project Summary Millions of endoscopic nasal sinus surgeries are performed annually worldwide, yet the outcomes are often variable. One reason is that predicting functional outcomes (e.g. nasal airflow) based solely on CT or endoscopy can be difficult. The lack of an objective planning system results in ineffective disease management. For this proposal, a unique multidisciplinary team of clinicians, computer scientists, and engineers was assembled to develop a virtual endoscopic sinus surgery simulator that would simulate patient anatomy, reveal flow obstructions, and ultimately facilitate optimization of the outcome of surgical approaches for treatment of nasal obstruction and conductive olfactory loss. Using virtual reality, the surgeon can remove obstructive tissue virtually through a haptic (tactile and kinesthetic) feedback device. After each virtual surgery, changes in nasal airflow can be computed and displayed and the process reiterated until an optimal result is reached. A trial using this approach was performed on four patients as a proof of concept, and a normative range of air/odor flow based on 22 healthy controls was established. We will continue to improve the overall fidelity of our system (Aim 1) by incorporating feedback from clinicians and iterative innovation employing recent advances in computer science (image processing, volume visualization, haptic modeling, interface design). We will also perform non-interventional trials on 20 patients and focus on nasal obstruction related olfactory loss (Aim 2) and test the hypothesis that the virtual sinus surgery simulator can improve treatment outcomes to conductive olfactory loss. While this proposal is limited to the specific symptom of obstruction-related olfactory loss, but in the future the tool can be expanded to improve outcomes for more generalized nasal obstruction symptoms. Ultimately, developing and validating such a virtual surgical planning system will prove invaluable for future surgical treatment of nasal obstruction and has the potential to directly improve clinical practice and offer personalized medicine.

项目总结