CSU Infectious Disease Research and Response Training Program

科罗拉多州立大学传染病研究和应对培训计划

• 批准号: 10657788
• 负责人: Gregg A Dean
• 金额: $ 46.52万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657788
• 关键词: Infectious Diseases Research; Training Programs; response

Contact PD/PI: Dean, Gregg A. Infectious Disease Research and Response Training Program (IDRRTP) The Infectious Disease Research and Response Network (IDRRN) was established in 2016 and has been recognized as a Program of Research and Scholarly Excellence (PRSE) at Colorado State University. The IDRRN promotes the development of interdisciplinary teams to investigate, study, and develop mitigation strategies for diseases locally, nationally and internationally. The IDRRN uses team dynamics to focus on infectious and neurodegenerative diseases and maximize the impact of its expertise in disease transmission and pathogenesis, development of diagnostics, vaccines and therapeutics, vector biology, epidemiology, and bio-engineering. The IDRRN has a strong commitment and a proven track record in training the next generation of research scientists who will continue to face pandemics while also confronting novel emerging infectious agents. In addition to the rich scientific environment, there are vast, state-of-the-art facilities featuring BLS2, BSL3, ABSL3 and GMP capabilities. The proposed training program will support 5 predoctoral trainees for three years. The IDRRTP faculty are a diverse group representing 7 departments from 3 colleges. Our preceptors include highly experienced senior training faculty and 4 well-funded assistant professors to ensure training of future research mentors. Trainees will complete personalized coursework training in microbiology, immunology, pathology, statistics and bioinformatics to provide foundational knowledge, build critical thinking skills, and ensure mastery of literature interrogation. Training in biosafety level 2 and 3 procedures, the responsible conduct of research, and methods to ensure rigor and reproducibility will be specifically addressed and emphasized throughout every aspect of the program. Trainees will participate in grant and manuscript writing courses that will yield submission-ready products. Communication skills will be nurtured and practiced to ensure confidence and effective engagement with scientific and lay audiences alike. A variety of other professional development opportunities and tools will be provided to encourage life-long growth, improvement and ultimate success. Finally, trainees will have opportunities to engage in research-to-market programs and medium-scale biomanufacturing experiences to gain an in-depth understanding of the translational process. Together, our training faculty, robust curriculum, synergistic training activities, and unique experiential opportunities will provide diverse cohorts of predoctoral trainees with the necessary skills to confront infectious disease threats to human health as they embark upon academic or non-academic research careers.

联系 PD/PI：Dean, Gregg A. 传染病研究和应对培训计划 (IDRRTP) 传染病研究和应对网络 (IDRRN) 成立于 2016 年， 已被科罗拉多州认定为研究和学术卓越计划 (PRSE) 州立大学。 IDRRN 促进跨学科团队的发展，以调查、 研究并制定地方、国家和国际疾病缓解战略。这 IDRRN 利用团队动力来关注传染病和神经退行性疾病， 最大限度地发挥其在疾病传播和发病机制方面的专业知识的影响，开发 诊断学、疫苗和治疗学、媒介生物学、流行病学和生物工程。这 IDRRN 在培训下一代方面拥有坚定的承诺和良好的记录 研究科学家将继续面临流行病，同时也面临新出现的问题 传染源。除了丰富的科学环境之外，还有广阔的、最先进的 设施具有 BLS2、BSL3、ABSL3 和 GMP 功能。拟议的培训计划将 三年资助5名博士前培训生。 IDRRTP 教师是一个多元化的群体 代表3所学院的7个院系。我们的导师包括经验丰富的资深人士 培训教师和 4 名资金充足的助理教授，以确保未来研究的培训 导师。学员将完成微生物学、免疫学、 病理学、统计学和生物信息学提供基础知识，建立批判性思维 技能，并确保掌握文献审讯。生物安全2级和3级培训 程序、负责任的研究行为以及确保严谨性和可重复性的方法 将在该计划的各个方面得到具体解决和强调。实习生 将参加资助和稿件写作课程，这些课程将产生可提交的产品。 将培养和练习沟通技巧，以确保信心和有效 与科学界和非专业观众的互动。各种其他专业发展 将提供机会和工具来鼓励终身成长、进步和最终 成功。最后，学员将有机会参与市场研究计划并 中等规模的生物制造经验，以深入了解 翻译过程。我们的培训师资力量、强大的课程、协同培训 活动和独特的体验机会将为博士前提供多样化的群体 受训人员具备应对传染病对人类健康威胁的必要技能 从事学术或非学术研究职业。

项目成果

Solutions to Enhance Health with Alternative Treatments (SEHAT) protocol: a double-blinded randomised controlled trial for gut microbiota-targeted treatment of severe acute malnutrition using rice bran in ready-to-use therapeutic foods in Indonesia.

• DOI: 10.1136/bmjopen-2023-076805
• 发表时间: 2023-11-24
• 期刊: BMJ open
• 影响因子: 2.9

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model.

• DOI: 10.3390/vaccines9040340
• 发表时间: 2021-04-01
• 期刊: Vaccines
• 影响因子: 7.8
• 作者: Ragan IK;Hartson LM;Dutt TS;Obregon-Henao A;Maison RM;Gordy P;Fox A;Karger BR;Cross ST;Kapuscinski ML;Cooper SK;Podell BK;Stenglein MD;Bowen RA;Henao-Tamayo M;Goodrich RP
• 通讯作者: Goodrich RP

Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis.

粘膜暴露于非结核分枝杆菌促成B细胞介导的肺结核的免疫力。

• DOI: 10.1016/j.celrep.2022.111783
• 发表时间: 2022-12-13
• 期刊: Cell reports
• 影响因子: 8.8

Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models.

• DOI: 10.1038/s41598-021-88291-8
• 发表时间: 2021-04-27
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Larsen SE;Reese VA;Pecor T;Berube BJ;Cooper SK;Brewer G;Ordway D;Henao-Tamayo M;Podell BK;Baldwin SL;Coler RN
• 通讯作者: Coler RN

Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters.

• DOI: 10.1038/s41541-021-00321-8
• 发表时间: 2021-03-30
• 期刊: NPJ vaccines
• 影响因子: 9.2
• 作者: Jia Q;Bielefeldt-Ohmann H;Maison RM;Masleša-Galić S;Cooper SK;Bowen RA;Horwitz MA
• 通讯作者: Horwitz MA