Molecular Biophysics Training Grant

分子生物物理学培训补助金

• 批准号: 7253150
• 负责人: Michael D. Brenowitz
• 金额: $ 34.42万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7253150
• 关键词: Biophysics; Grant; Molecular; Training

DESCRIPTION (provided by applicant): This application requests continued support for a Ph.D. Training Program in Molecular Biophysics, which is currently in its tenth year of existence. The training faculty in this proposal primarily have appointments in two closely allied departments, Biochemistry and Physiology & Biophysics. Through required and elective courses, participation in research seminars and discussion groups and, most importantly, through individual research, the student trainees develop the technical skills and critical ability necessary to conduct independent research in Molecular Biophysics. Training consists of three to four years of individual research, often with joint mentoring, after a first year that consists entirely of coursework and laboratory rotations. Both the course work and research training of each student are closely monitored by the Steering Committee for the program. The cohesiveness of the program is assured by regular meetings of the training faculty and trainees under the guidance of the Steering Committee as well as by Core courses taken by all trainees. This program provides valuable training opportunities for students in Molecular Biophysics due to the outstanding faculty and facilities that exist at the Institution In two areas in particular, the program provides unparalleled opportunities. These include synchrotron and laser spectroscopy research. Beamline facilities operated by the College of Medicine at the National Synchrotron Light Source include student access to state-of-the art protein crystallography, x-ray absorption spectroscopy x-ray footprinting, and infrared microspectroscopy techniques. Also, the laser facilities of the College include several laboratories with state-of-the art femtosecond to microsecond time-resolved instrumentation for the study of protein folding and dynamics for student research. The research areas that are especially strong in the trainer's laboratories are Structural Biology, including macromolecular NMR and crystallography time-resolved investigations of protein and nucleic acid folding and protein dynamics; structure function relationships of metalloproteins, metalloenzymes, and enzymes; and allostenc interactions of macromolecules The two departments involved in this proposal are currently attracting excellent trainee candidates and have trained numerous students in the past who have excellent outcomes. The program currently provides training for six pre-doctoral students in each year; this proposal suggests an increase to seven slots per year.

描述（由申请人提供）：本申请要求继续支持博士学位。分子生物物理学培训方案，目前已进入第十个年头。本提案中的培训教师主要在两个密切相关的部门任职，生物化学和生理学与生物物理学。通过必修课和选修课，参加研究研讨会和讨论小组，最重要的是，通过个人研究，学生学员发展必要的技术技能和关键能力，进行分子生物物理学的独立研究。培训包括三到四年的个人研究，通常有联合指导，第一年完全由课程和实验室轮换组成。每个学生的课程工作和研究培训都由该计划的指导委员会密切监测。该计划的凝聚力是由培训教师和学员在指导委员会的指导下，以及通过所有学员采取的核心课程定期会议保证。该计划提供了宝贵的培训机会，为学生在分子生物物理学由于优秀的教师和设施，存在于该机构在两个领域，特别是，该计划提供了无与伦比的机会。其中包括同步加速器和激光光谱学研究。由国家同步加速器光源医学院运营的光束线设施包括学生获得最先进的蛋白质晶体学，x射线吸收光谱x射线足迹和红外显微光谱技术。此外，该学院的激光设施包括几个实验室，这些实验室拥有最先进的飞秒到微秒时间分辨仪器，用于学生研究蛋白质折叠和动力学的研究。在培训师的实验室中特别强大的研究领域是结构生物学，包括蛋白质和核酸折叠和蛋白质动力学的大分子NMR和晶体学时间分辨研究;金属蛋白质，金属酶和酶的结构功能关系;参与该提案的两个部门目前正在吸引优秀的实习生候选人，并已培训了许多学生在过去谁有出色的成果。该计划目前每年为六名博士预科生提供培训;这项提案建议每年增加到七个名额。