Molecular Biophysics Training Grant

描述（由申请人提供）：本提案是对西北大学分子生物物理学博士前培训项目的支持请求。过去的培训补助金支持在促进温伯格艺术与科学学院、麦考密克工程学院和范伯格医学院五个参与院系的教师、学生和博士后研究员之间的跨学科互动方面发挥了重要作用。生物、化学和工程系聘用了许多对分子生物物理学有研究兴趣的教员，形成了一个高度互动的研究环境，重点关注定量物理方法和方法在大分子结构和功能问题上的应用。生物物理学培训计划受益于使用最先进的设备设施，包括凯克生物物理学设施内的仪器、先进光子源的两条用于大分子晶体学的光束线和其他关键研究资源。 该培训计划有一个核心生物物理学课程，供参加每个研究生课程的学生遵循，为具有不同教育背景的学生提供共同的教学体验。该项目关键研究领域（例如结构生物学）的高级研究生水平课程是培训经验的核心。学生还参加每月的生物物理学俱乐部和期刊俱乐部会议，并参加生物物理学研讨会系列作为该计划的一部分。要求在研究生教育的第二年至第四年为生物物理学学生提供支持，加强培训计划在指导学生完成研究生学习关键阶段的作用。生物物理学研究生的培训为他们研究与广泛的公共卫生问题相关的生物过程提供了定量基础。生物物理方法在现代药物发现和设计中至关重要，接受过这些方法培训的研究生有能力进一步加深我们对各种人类疾病的理解和干预。

DESCRIPTION (provided by applicant): This proposal is a request for support of the Northwestern University pre-doctoral training program in Molecular Biophysics. Past support from the training grant has played a major role in stimulating interdisciplinary interactions between faculty, students and post-doctoral fellows within five participating departments in the Weinberg College of Arts and Sciences, the McCormick School of Engineering and the Feinberg School of Medicine. The hiring of many faculty in biology, chemistry and engineering departments with research interests in molecular biophysics has generated a highly-interactive research environment focused on the application of quantitative physical methods and approaches to problems of macromolecular structure and function. The Biophysics Training Program benefits from access to state-of-the-art equipment facilities, including instrumentation within the Keck Biophysics Facility, two beamlines for macromolecular crystallography at the Advanced Photon Source and other key research resources. The training program has a core biophysics curriculum to be followed by students entering through each of the participating graduate programs, providing a common didactic experience to students with diverse educational backgrounds. Advanced graduate-level courses in key research areas of the program, such as structural biology are central to the training experience. Students also participate in monthly Biophysics Club and Journal Club meetings, and attend a Biophysics Seminar Series as part of the program. Support for biophysics students is requested for the 2nd-4th years of graduate education, enhancing the Training Program role in mentoring students through key stages of their graduate studies. The training of graduate students in Biophysics provides them a quantitative foundation for studying biological processes relevant to a wide range of public health issues. Biophysical methods are centrally important in modern drug discovery and design, and graduate students trained in these methods are well positioned to further our understanding and intervention in a wide range of human diseases.