Renal Sodium Transport in the Obese Zucker Rat
Renal Sodium Transport in the Obese Zucker Rat
批准号:
7340799
负责人:
Carolyn Mary Ecelbarger
金额:
$2.33万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-06-01 至 2008-05-31
关键词:
AcuteAgeAgonistAldosteroneAngiotensin IIAngiotensin-Converting Enzyme InhibitorsAngiotensinsAutoradiographyBindingBlood PressureCanrenoneCarrier ProteinsCollagen Type IVDataDiabetes MellitusDietDisease modelDistalDown-RegulationEnalaprilEndocrineEnzymesEpithelialEquilibriumEtiologyFibronectinsGlucocorticoidsGoalsHomeostasisHormonesHyperinsulinismHypertensionHypertrophyIn SituIn Situ HybridizationIn VitroInfusion proceduresInsulinInsulin ReceptorInsulin ResistanceKidneyKidney DiseasesLaboratoriesLocationMessenger RNAMineralocorticoid ReceptorMineralocorticoidsModelingMolecularNa(+)-K(+)-Exchanging ATPaseNatriuresisObesityPPAR gammaPartner in relationshipPathologyPatternPhosphorylationPlasmaPlayProcessProtein Tyrosine KinaseProteinsRangeRattusReceptor SignalingRegulationRelative (related person)Renal HypertensionRenal tubule structureReninRenin-Angiotensin-Aldosterone SystemResearch PersonnelRoleSeriesSignal TransductionSignaling ProteinSodiumSodium ChannelSodium ChlorideSteroidsSystemTestingUp-RegulationVasopressinsWaterWeekZucker Ratsage relatedagedblood pressure regulationcandesartandaydesigndietary restrictionepithelial Na+ channelmRNA Expressionpreventprogramsprotein expressionreceptorreceptor bindingreceptor expressionresponserosiglitazonesalureticthiazidewater channel
中文摘要
肥胖和胰岛素抵抗与高血压有关。不适当的钠潴留
英文摘要
Obesity and insulin resistance are associated with hypertension. Inappropriate retention of sodium by the
kidney is likely to play a major role. We previously showed that the obese Zucker rat (a model for these
disorders) have increased renal protein abundance for three major sodium transport proteins: the alpha-1
subunit of Na-K-ATPase, the thiazide-sensitive NaCI cotransporter (NCC or TSC) and the beta-subunit of the
epithelial sodium channel (ENaC). In contrast, as, they aged, obese rats developed renal hypertrophy along
with diabetes and had a relative decrease in many important salt and water transport proteins, as compared
to age-matched controls. We suggest that dysregulation of several important hormone systems in sodium
balance may play a role in both alterations in sodium transport protein expression, as well as, the rapid
develop of nephropathy. Candidate systems include the renin-angiotensin-aldosterone system (RAAS) and
insulin (and or insulin resistance). We hypothesize that dysregulation of major sodium transport proteins of
the kidney in the obese Zucker rat with age, is due at least in part to increased RAAS activity, and
hyperinsulinemia, which in combination, result in inappropriate sodium retention and elevated blood
pressure. Our specific aims include: 1) to determine if angiotensin II ATla receptor expression, binding, and
activity is upregulated in the obese Zucker rat and whether this upregulation plays a role in changes in renal
sodium transporter regulation, blood pressure, and renal hypertrophy; 2) to determine if enhanced
mineratocorticoid receptor (MR) activity plays a role in increased whole kidney protein abundance of the
thiazide-sensitive NaCI cotransporter (NCC), blood pressure, and renal hypertrophy, in the obese Zucker rat;
3) to determine the cellular location and sensitivity of the renal insulin receptor in obese Zucker rats relative
to lean age-mates; 4) to determine whether treatment of insulin resistance with a PPAR-gamma agonist will
decrease relative renal protein abundance of NCC, beta-ENaC, and Na-K-ATPase, as well as reduce blood
pressure and renal hypertrophy in the obese Zucker rat, and whether these effects are reversed with short-
term insulin infusion. These studies will allow us to determine the importance of each of these potential
regulatory hormone systems in dyregulation of sodium transporter expression, sodium balance, and blood
pressure in these obese rats.
期刊论文(22)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1016/s1550-8579(06)80219-6
发表时间:
2006-12-01
期刊:
Gender medicine
影响因子:
--
作者:
[Riazi, Shahla, Madala-Halagappa, Veerendra K, Ecelbarger, Carolyn A]
通讯作者:
Ecelbarger, Carolyn A
Sex and age result in differential regulation of the renal thiazide-sensitive NaCl cotransporter and the epithelial sodium channel in angiotensin II-infused mice.
性别和年龄导致血管紧张素 II 输注小鼠肾噻嗪类敏感 NaCl 协同转运蛋白和上皮钠通道的差异调节。
DOI:
10.1159/000252776
发表时间:
2009
期刊:
American journal of nephrology
影响因子:
4.2
作者:
[Tiwari,Swasti, Li,Lijun, Riazi,Shahla, Halagappa,VeerendraKMadala, Ecelbarger,CarolynM]
通讯作者:
Ecelbarger,CarolynM
Chronic rosiglitazone therapy normalizes expression of ACE1, SCD1 and other genes in the kidney of obese Zucker rats as determined by microarray analysis.
通过微阵列分析确定,长期罗格列酮治疗可使肥胖 Zucker 大鼠肾脏中 ACE1、SCD1 和其他基因的表达正常化。
DOI:
10.1055/s-2008-1042429
发表时间:
2008
期刊:
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
影响因子:
--
作者:
[Song,J, Liu,H, Ressom,HW, Tiwari,S, Ecelbarger,CM]
通讯作者:
Ecelbarger,CM
DOI:
10.1016/j.phrs.2008.03.013
发表时间:
2008-05
期刊:
Pharmacological research
影响因子:
9.3
作者:
[Swasti Tiwari;E. Blasi;J. Heyen;A. Mcharg;C. Ecelbarger]
通讯作者:
Swasti Tiwari;E. Blasi;J. Heyen;A. Mcharg;C. Ecelbarger
Sex differences in renal nitric oxide synthase, NAD(P)H oxidase, and blood pressure in obese Zucker rats.
肥胖 Zucker 大鼠肾一氧化氮合酶、NAD(P)H 氧化酶和血压的性别差异。
DOI:
10.1016/s1550-8579(07)80042-8
发表时间:
2007
期刊:
Gender medicine. official journal of the Partnership for Gender-Specific Medicine at Columbia University
影响因子:
--
作者:
[Riazi,Shahla, Madala-Halagappa,VeerendraK, Dantas,AnaPaula, Hu,Xinqun, Ecelbarger,CarolynA]
通讯作者:
Ecelbarger,CarolynA
共 12 条
Role of Insulin Receptors in the Kidney
-
批准号:8293359
-
项目类别:
-
资助金额:$32.75万
-
财政年份:2010
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Role of Insulin Receptors in the Kidney
-
批准号:8072593
-
项目类别:
-
资助金额:$31.15万
-
财政年份:2010
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Role of Insulin Receptors in the Kidney
-
批准号:7887108
-
项目类别:
-
资助金额:$37.9万
-
财政年份:2010
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Role of Insulin Receptors in the Kidney
-
批准号:8484832
-
项目类别:
-
资助金额:$30.43万
-
财政年份:2010
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Role of Insulin Receptors in the Kidney
-
批准号:8326300
-
项目类别:
-
资助金额:$0.8万
-
财政年份:2010
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
NaCI Balance and Targeted Insulin Receptor Knockout Mice
-
批准号:6673317
-
项目类别:
-
资助金额:$14.14万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Renal Sodium Transport in the Obese Zucker Rat
-
批准号:6900324
-
项目类别:
-
资助金额:$31.04万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Insulin, Renal Sodium Transport and Blood Pressure
-
批准号:6785515
-
项目类别:
-
资助金额:$25.26万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Renal Sodium Transport in the Obese Zucker Rat
-
批准号:7073450
-
项目类别:
-
资助金额:$30.31万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Insulin, Renal Sodium Transport and Blood Pressure
-
批准号:6929844
-
项目类别:
-
资助金额:$24.87万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Renal Sodium Transport in the Obese Zucker Rat
-
批准号:6602611
-
项目类别:
-
资助金额:$29.66万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Renal Sodium Transport in the Obese Zucker Rat
-
批准号:6747709
-
项目类别:
-
资助金额:$31.04万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Insulin, Renal Sodium Transport and Blood Pressure
-
批准号:7103515
-
项目类别:
-
资助金额:$23.8万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Renal Sodium Transport in the Obese Zucker Rat
-
批准号:7239683
-
项目类别:
-
资助金额:$33.8万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
NaCI Balance and Targeted Insulin Receptor Knockout Mice
-
批准号:6762353
-
项目类别:
-
资助金额:$15.52万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
Insulin, Renal Sodium Transport and Blood Pressure
-
批准号:6674786
-
项目类别:
-
资助金额:$23.88万
-
财政年份:2003
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
REGULATION OF THE RENAL SALT AND WATER TRANSPORTERS
-
批准号:6380116
-
项目类别:
-
资助金额:$8.86万
-
财政年份:1999
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
REGULATION OF THE RENAL SALT AND WATER TRANSPORTERS
-
批准号:2840956
-
项目类别:
-
资助金额:$8.86万
-
财政年份:1999
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
REGULATION OF THE RENAL SALT AND WATER TRANSPORTERS
-
批准号:6176963
-
项目类别:
-
资助金额:$8.86万
-
财政年份:1999
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
RENAL TUBULAR EXPRESSION OF V-1A VASOPRESSIN RECEPTOR
-
批准号:2135715
-
项目类别:
-
资助金额:$2.76万
-
财政年份:1995
-
负责人:Carolyn Mary Ecelbarger
-
依托单位:
国内基金
海外基金
登录
查看更多内容
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
-
批准号:JCZRLH202601523
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
-
批准号:JCZRQN202500010
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
-
批准号:2025JJ70209
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:雷芬芳
-
依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:--
-
批准年份:2024
-
负责人:万荣
-
依托单位:
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
-
批准号:2023JJ50274
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:贺志明
-
依托单位:
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
-
批准号:--
-
项目类别:地区科学基金项目
-
资助金额:33万元
-
批准年份:2022
-
负责人:都义日
-
依托单位:
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:叶宝东
-
依托单位:
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:于海兵
-
依托单位:
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
-
批准号:81973577
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:辛贵忠
-
依托单位:
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
-
批准号:81602908
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2016
-
负责人:刘括
-
依托单位: