Neural Mechanisms of Fear Renewal in Humans

人类恐惧更新的神经机制

• 批准号: 7294927
• 负责人: NICOLE Cynthia HUFF
• 金额: $ 4.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-28 至 2009-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7294927
• 关键词: Amygdaloid structure; Animals; Anxiety; Anxiety Disorders; Brain; Clinical; Conditioned Stimulus; Cues; Disease; Distal; Diving; Environment; Experimental Designs; Extinction (Psychology); Fellowship; Fright; Functional Magnetic Resonance Imaging; Galvanic Skin Response; Goals; Goggles; Hippocampus (Brain); Human; Image; Individual; Investigation; Knowledge; Laboratories; Learning; Link; Literature; Measures; Medial; Modeling; Names; Neurons; Output; Participant; Patients; Pattern; Phase; Population; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Public Health; Rodent; Scanning; Stimulus; System; Testing; Training; clinically relevant; conditioned fear; design; experience; experimental analysis; human subject; neural circuit; neuroimaging; neuromechanism; novel; relating to nervous system; research study; response; virtual; virtual reality

DESCRIPTION (provided by applicant): Extinction of fear, the process by which conditioned fear is no longer evoked in response to a conditioned stimulus, has received considerable experimental investigation in both rodents and humans. However, the return of fear after extinction, termed renewal, has received less experimental analysis, particularly in human subjects. Fear renewal is a major public health concern because it occurs after extinction therapy in populations with PTSD and other anxiety related disorders. Evidence in rodents suggests that after extinction contextual cues regulate the renewal of fear and this process is hippocampus-dependent. The specific aims of this proposal will (1) demonstrate fear renewal in human subjects in a clinically relevant and hippocampus- dependent paradigm in the laboratory, (2) investigate how contextual cues regulate the renewal of conditioned fear using virtual reality contexts, (3) implement virtual contexts within an fMRI scanner to investigate the pattern of brain activation during fear renewal. The proposed studies will contribute to understanding basic mechanisms that support fear renewal. Moreover, the findings will provide a direct link between evidence from rodent studies and application for a clinical setting.

描述（由申请人提供）：恐惧的灭绝，这是对条件刺激的响应不再引起条件恐惧的过程，在啮齿动物和人类中都接受了相当大的实验研究。然而，灭绝后的恐惧恢复称为续约，尤其是在人类受试者中进行的实验分析较少。恐惧更新是一个主要的公共卫生问题，因为它发生在PTSD和其他与焦虑症相关的疾病的人群中灭绝治疗后发生。啮齿动物中的证据表明，在灭绝之后，情境线索调节了恐惧的更新，而这一过程是海马依赖的。该提议的具体目的（1）将在实验室中表现出临床相关和海马依赖性范式中人类受试者的恐惧，（2）调查上下文提示如何调节有条件的恐惧使用虚拟现实背景的续签，（3）在fmri scanner to thefor the of Brain Action of Brain Activation of Brain Activation of Brain Activation in thece in the of Brain Action of Brain Activation rene nece rene rene rene rene sive rene sive rene。拟议的研究将有助于理解支持恐惧更新的基本机制。此外，这些发现将在啮齿动物研究中的证据与临床环境的应用之间提供直接联系。