Exploration, conservation, and development of marine bi*

海洋生物的勘探、保护和开发*

基本信息

  • 批准号:
    7285630
  • 负责人:
  • 金额:
    $ 79.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-09-29 至 2009-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Overall objectives are to discover small molecule drug leads against a targeted group of diseases critical to developing nations and to the United States, by using ecological insights to guide the investigation of novel natural products from biodiverse coral reef organisms and marine microbes of Fiji. The project also helps build local institutions and attitudes to conserve marine biodiversity of the South Pacific, and undertakes this goal in ways that provide positive economic incentives for the owners of these marine environments. These efforts will found the South Pacific Center for Biodiversity Conservation and Drug Discovery at the University of the South Pacific (USP). This center will serve the 12 island nations that own USP (Cook Islands, Fiji, Kiribati, Marshall Islands, Nauru, Niue, Samoa, Solomon Islands, Tokelau, Tonga, Tuvalu and Vanuatu), and be an independent and self-sustaining unit by the end of the ICBG grant. Specific aims are: To collect, extract, and bioassay 500 samples from marine actinomycetes and 500 samples from coral reef plants and invertebrates each year. To use ecological approaches to induce a greater diversity and potency of natural products from marine organisms for exploration as drug leads. To perform bioassay-guided isolation of active constituents and determine the structure of 25 new bioactive molecules per year. To test these novel natural products against cancer, malaria, HIV-AIDS, tuberculosis, and other infectious disease-causing organisms including drug-resistant Staphylococcus aureus, Enterococcus faecium, and Candida albicans. To promote scientifically-informed coral reef conservation, management, biological monitoring, and alternative income generation that is biodiversity-based and ecologically sustainable. To transfer appropriate technology to Fiji and the proposed South Pacific Center for Biodiversity Conservation and Drug Discovery.
描述(由申请人提供):总体目标是利用生态学见解指导对斐济生物多样性珊瑚礁生物和海洋微生物的新型天然产物的调查,发现针对对发展中国家和美国至关重要的一组目标疾病的小分子药物先导物。该项目还有助于建立保护南太平洋海洋生物多样性的当地机构和态度,并以为这些海洋环境的所有者提供积极经济激励的方式实现这一目标。这些努力将在南太平洋大学(USP)建立南太平洋生物多样性保护和药物发现中心。该中心将为拥有USP的12个岛国(库克群岛、斐济、基里巴斯、马绍尔群岛、瑙鲁、纽埃、萨摩亚、所罗门群岛、托克劳、汤加、图瓦卢和瓦努阿图)提供服务,并在ICBG赠款结束时成为一个独立和自我维持的单位。具体目标是:每年从海洋放线菌和珊瑚礁植物和无脊椎动物中收集、提取和生物测定500个样本。利用生态方法诱导海洋生物天然产物的更大多样性和效力,作为药物先导进行探索。每年进行生物测定指导下的活性成分分离,并确定25个新的生物活性分子的结构。为了测试这些新的天然产物对癌症、疟疾、艾滋病、结核病和其他传染性疾病的致病生物,包括耐药金黄色葡萄球菌、屎肠球菌和白色念珠菌的作用。促进以科学为依据的珊瑚礁养护、管理、生物监测,以及基于生物多样性和生态可持续的其他创收方式。向斐济和拟议中的南太平洋生物多样性保护和药物发现中心转让适当的技术。

项目成果

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科研奖励数量(0)
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专利数量(0)

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MARK E HAY其他文献

MARK E HAY的其他文献

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{{ truncateString('MARK E HAY', 18)}}的其他基金

Exploration, conservation, & development of marine biodiversity in Fiji
探索、保护、
  • 批准号:
    7908261
  • 财政年份:
    2009
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji
探索、保护、
  • 批准号:
    7741942
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji and the S
探索、保护、
  • 批准号:
    8918760
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji
探索、保护、
  • 批准号:
    8478226
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, and development of marine bi*
海洋生物的勘探、保护和开发*
  • 批准号:
    7022023
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji and the S
探索、保护、
  • 批准号:
    9122517
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji and the S
探索、保护、
  • 批准号:
    8785211
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji
探索、保护、
  • 批准号:
    8287154
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji
探索、保护、
  • 批准号:
    7929594
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:
Exploration, conservation, & development of marine biodiversity in Fiji
探索、保护、
  • 批准号:
    8109972
  • 财政年份:
    2005
  • 资助金额:
    $ 79.02万
  • 项目类别:

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  • 财政年份:
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初始定殖者口放线菌在牙菌斑形成中的作用。
  • 批准号:
    24592790
  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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  • 批准号:
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  • 财政年份:
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  • 批准号:
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  • 批准号:
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  • 批准号:
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  • 批准号:
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