Mentoring in Drug Abuse and Dual Diagnosis Research

描述(由申请人提供)：这是罗杰·韦斯医学博士的K24职业生涯中期研究人员奖的申请书。韦斯博士是哈佛医学院精神病学教授和马萨诸塞州贝尔蒙特麦克莱恩医院酒精和药物滥用治疗计划的临床主任。韦斯博士致力于以患者为导向的药物滥用研究。自1989年以来，他一直得到NIDA的持续支持，并成功地指导了一些已经成为独立的、全国知名的调查人员。他的研究重点是评估和治疗1)可卡因依赖患者和2)同时患有精神疾病的药物依赖患者。他研究了药物依赖和双重诊断患者的不同治疗模式的整合(即，精神科和药物滥用方法，药物治疗和行为治疗，专业治疗和自助方法)。这一奖项的主要目的是使Weiss博士能够在继续从事这一研究计划的同时扩大他的指导能力。近年来，韦斯博士指导了越来越多来自麦克莱恩医院和其他地方的初级调查人员。他目前的大部分指导都是在他自己的项目的背景下进行的。K24奖将使他能够1)花更多的时间与他的辅导者在一起；2)在他自己的项目范围之外指导初级调查人员，帮助他们在以患者为导向的研究中发展独立的调查事业；以及3)接受更多他目前无法容纳的辅导者。指导将在NIH资助的三个项目的背景下进行，Weiss博士是该项目的首席研究员：1)NIDA临床试验网络，其中他是新英格兰北部节点的PI，并领导了一项阿片类止痛剂依赖治疗的多站点研究；2)他由NIDA资助的针对双相情感障碍和物质依赖患者的集体治疗的R01研究；以及3)多站点NIAAA联合研究，其中他是哈佛站点的PI。作为K24奖的一部分，韦斯博士将在1)慢性疼痛、2)脑成像和3)统计学领域接受额外的培训，这将同时加强他自己的研究技能，并提高他的指导能力。

DESCRIPTION (provided by applicant): This is an application for a K24 Mid-Career Investigator Award in Patient-Oriented Research for Roger Weiss, M.D. Dr. Weiss is Professor of Psychiatry at Harvard Medical School and Clinical Director of the Alcohol and Drug Abuse Treatment Program at McLean Hospital, Belmont, Massachusetts. Dr. Weiss has devoted his career to patient-oriented drug abuse research. He has had continuous NIDA support since 1989, and has successfully mentored individuals who have become independent, nationally known investigators. His research has focused on the evaluation and treatment of 1) cocaine-dependent patients and 2) substance-dependent patients with co-occurring psychiatric illness. He has studied the integration of different models of treatment (i.e., psychiatric with substance abuse approaches, pharmacotherapy with behavioral therapy, professional treatment with self-help approaches) for drug-dependent and dually diagnosed patients. The primary aim of this award is to enable Dr. Weiss to expand his mentoring capacity while continuing to engage in this program of research. In recent years, Dr. Weiss has mentored an increasing number of junior investigators from McLean Hospital and elsewhere. Much of his current mentoring takes place in the context of his own projects. A K24 Award would enable him to 1) spend more time with his mentees; 2) mentor junior investigators outside the confines of his own projects, in the service of helping them to develop independent investigative careers in patient-oriented research; and 3) take on additional mentees that he currently cannot accommodate. Mentoring will take place in the context of three NIH-funded projects on which Dr. Weiss is Principal Investigator: 1) the NIDA Clinical Trials Network, in which he is PI of the Northern New England Node and Lead Investigator of a multi-site study of treatments for opioid analgesic dependence; 2) his NIDA-funded R01 study of group therapy for patients with bipolar disorder and substance dependence; and 3) the multi-site NIAAA COMBINE study, in which he is PI of the Harvard site. As part of the K24 Award, Dr. Weiss will receive additional training in the areas of 1) chronic pain, 2) brain imaging, and 3) statistics, which will simultaneously strengthen his own research skills and improve his mentoring abilities.