Mentoring in Drug Abuse and Dual Diagnosis Research

描述（由申请人提供）：这是Roger Weiss医学博士的一份申请K24面向患者研究中期职业研究者奖的申请。Weiss博士是哈佛医学院精神病学教授，也是马萨诸塞州贝尔蒙特市麦克莱恩医院酒精和药物滥用治疗项目的临床主任。韦斯博士致力于以病人为导向的药物滥用研究。自1989年以来，他一直得到NIDA的支持，并成功地指导了一些独立的、全国知名的调查人员。他的研究主要集中在评估和治疗1)可卡因依赖患者和2)物质依赖患者同时发生的精神疾病。他研究了药物依赖和双重诊断患者的不同治疗模式的整合（即，精神病学与药物滥用方法，药物治疗与行为治疗，专业治疗与自助方法）。该奖项的主要目的是使Weiss博士能够在继续从事该研究项目的同时扩大他的指导能力。近年来，韦斯博士指导了越来越多来自麦克莱恩医院和其他地方的初级调查员。他目前的许多指导都是在他自己的项目背景下进行的。K24奖将使他能够1)花更多的时间与他的学员在一起；2)在他自己的项目范围之外指导初级调查人员，帮助他们在以患者为导向的研究中发展独立的调查事业；3)接受目前无法容纳的额外学员。指导将在nih资助的三个项目的背景下进行，Weiss博士是主要研究者：1)NIDA临床试验网络，他是新英格兰北部节点的PI和阿片类镇痛药物依赖治疗的多站点研究的首席研究员；2) nida资助的双相情感障碍和物质依赖患者群体治疗的R01研究；3)多站点NIAAA COMBINE研究，他是哈佛站点的PI。作为K24奖的一部分，Weiss博士将在1)慢性疼痛，2)脑成像和3)统计领域接受额外的培训，这将同时加强他自己的研究技能并提高他的指导能力。

DESCRIPTION (provided by applicant): This is an application for a K24 Mid-Career Investigator Award in Patient-Oriented Research for Roger Weiss, M.D. Dr. Weiss is Professor of Psychiatry at Harvard Medical School and Clinical Director of the Alcohol and Drug Abuse Treatment Program at McLean Hospital, Belmont, Massachusetts. Dr. Weiss has devoted his career to patient-oriented drug abuse research. He has had continuous NIDA support since 1989, and has successfully mentored individuals who have become independent, nationally known investigators. His research has focused on the evaluation and treatment of 1) cocaine-dependent patients and 2) substance-dependent patients with co-occurring psychiatric illness. He has studied the integration of different models of treatment (i.e., psychiatric with substance abuse approaches, pharmacotherapy with behavioral therapy, professional treatment with self-help approaches) for drug-dependent and dually diagnosed patients. The primary aim of this award is to enable Dr. Weiss to expand his mentoring capacity while continuing to engage in this program of research. In recent years, Dr. Weiss has mentored an increasing number of junior investigators from McLean Hospital and elsewhere. Much of his current mentoring takes place in the context of his own projects. A K24 Award would enable him to 1) spend more time with his mentees; 2) mentor junior investigators outside the confines of his own projects, in the service of helping them to develop independent investigative careers in patient-oriented research; and 3) take on additional mentees that he currently cannot accommodate. Mentoring will take place in the context of three NIH-funded projects on which Dr. Weiss is Principal Investigator: 1) the NIDA Clinical Trials Network, in which he is PI of the Northern New England Node and Lead Investigator of a multi-site study of treatments for opioid analgesic dependence; 2) his NIDA-funded R01 study of group therapy for patients with bipolar disorder and substance dependence; and 3) the multi-site NIAAA COMBINE study, in which he is PI of the Harvard site. As part of the K24 Award, Dr. Weiss will receive additional training in the areas of 1) chronic pain, 2) brain imaging, and 3) statistics, which will simultaneously strengthen his own research skills and improve his mentoring abilities.