Graduated Recovery Intervention for Early Schizophrenia

早期精神分裂症的分级康复干预

• 批准号: 7215212
• 负责人: DAVID Lewis PENN
• 金额: $ 18.94万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7215212
• 关键词: Address; Adherence; Alcohol or Other Drugs use; Attitude; Chronic; Chronic Schizophrenia; Client; Clinical; Counseling; Data; Development; Disease; Disease remission; Early Intervention; Economics; Feedback; Goals; Grant; Health Expenditures; Individual; Intervention; Lead; Manuals; Mediator of activation protein; Mental Health; Morbidity - disease rate; NIH Program Announcements; Nature; Neurocognition; Numbers; Outcome; Outcome Measure; Participant; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Phase; Psychotic Disorders; Public Health; Purpose; Randomized; Randomized Controlled Trials; Rate; Recovery; Recovery of Function; Recruitment Activity; Relapse; Research; Research Personnel; Residual state; Schizoaffective Disorders; Schizophrenia; Schizophreniform Disorder; Social Functioning; Staging; Symptoms; Testing; Therapeutic; Training; Treatment Protocols; United States; base; cost; first episode schizophrenia; follow-up; hospital readmission; improved; intervention program; medication compliance; mortality; programs; psychosocial; response; severe mental illness; size; therapy development

DESCRIPTION (provided by applicant): The proposed research has the following goals: 1) Develop and standardize a manual-based individual therapy for first-episode (FE) schizophrenia that is sensitive to the early stages of recovery from initial psychosis (i.e., the "Graduated Recovery Intervention Program;" GRIP); 2) Pilot test GRIP in a small-scale randomized controlled trial (RCT) to obtain specific intervention parameters, including effect sizes and attrition rates, as well as preliminary efficacy data; and 3) Collect preliminary data on intervention moderators and mediators. To achieve these goals, we will conduct the proposed research in three stages. During the first stage, we will refine and standardize the GRIP manual. In the second stage, we will conduct an open, uncontrolled pilot test of the intervention on 6 patients. Following the open trial, we will develop a final version of the GRIP manual. In the third phase of the research, we will conduct a small pilot randomized controlled trial of GRIP (n=25) versus supportive counseling (SC; n=25) for individuals with FE schizophrenia spectrum disorders (i.e., schizophrenia; schizoaffective disorder; schizophreniform disorder). Participants will be assessed at baseline, mid-treatment, post-treatment, and three-month follow-up on a variety of outcome measures, including social functioning, substance use, medication attitudes and adherence, rehospitalization, and symptoms.

描述（由申请人提供）：拟议的研究有以下目标：1)开发和标准化基于手册的首发精神分裂症（FE）个体化治疗，该治疗对初始精神病恢复的早期阶段敏感(即“渐进式恢复干预计划”；控制);2)在小规模随机对照试验（RCT）中对GRIP进行先导试验，获得具体的干预参数，包括效应量和损耗率，以及初步疗效数据；3)收集干预调节因子和中介因子的初步数据。为了达到这些目标，我们将分三个阶段进行拟议的研究。在第一阶段，我们将完善和标准化GRIP手册。在第二阶段，我们将对6名患者进行公开的、不受控制的干预试验。在公开试用之后，我们将开发GRIP手册的最终版本。在研究的第三阶段，我们将对FE精神分裂症谱系障碍（即精神分裂症、分裂情感障碍、精神分裂症样障碍）患者进行GRIP （n=25）与支持性咨询（SC; n=25）的小型随机对照试验。参与者将在基线、治疗中期、治疗后和三个月的随访中进行各种结果测量的评估，包括社会功能、物质使用、药物态度和依从性、再住院和症状。

项目成果

A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis.

• DOI: 10.1016/j.schres.2010.08.006
• 发表时间: 2011-02
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Penn DL;Uzenoff SR;Perkins D;Mueser KT;Hamer R;Waldheter E;Saade S;Cook L
• 通讯作者: Cook L

The graduated recovery intervention program for first episode psychosis: treatment development and preliminary data.

首发精神病的分级恢复干预计划：治疗发展和初步数据。

• DOI: 10.1007/s10597-008-9147-6
• 发表时间: 2008
• 期刊: Community mental health journal
• 影响因子: 2.7
• 作者: Waldheter,EvanJ;Penn,DavidL;Perkins,DianaO;Mueser,KimT;Owens,LeanneWhaley;Cook,Elizabeth
• 通讯作者: Cook,Elizabeth

Evaluation of a multi-element treatment center for early psychosis in the United States.

对美国早期精神病多要素治疗中心的评估。

• DOI: 10.1007/s00127-011-0467-4
• 发表时间: 2012
• 期刊: Social psychiatry and psychiatric epidemiology
• 影响因子: 4.4
• 作者: Uzenoff,SarahR;Penn,DavidL;Graham,KarenA;Saade,Sylvia;Smith,BarbaraB;Perkins,DianaO
• 通讯作者: Perkins,DianaO