Graduated Recovery Intervention for Early Schizophrenia

早期精神分裂症的分级康复干预

• 批准号: 7059851
• 负责人: DAVID Lewis PENN
• 金额: $ 23.37万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7059851
• 关键词: behavioral /social science research tag; clinical research; clinical trials; counseling; disease /disorder onset; educational resource design /development; functional ability; handbook; health behavior; health care personnel education; hospital utilization; human subject; human therapy evaluation; medical rehabilitation related tag; patient oriented research; psychosocial rehabilitation; relapse /recurrence; schizophrenia; sign /symptom; social behavior; substance abuse related disorder; therapy compliance; therapy design /development

DESCRIPTION (provided by applicant): The proposed research has the following goals: 1) Develop and standardize a manual-based individual therapy for first-episode (FE) schizophrenia that is sensitive to the early stages of recovery from initial psychosis (i.e., the "Graduated Recovery Intervention Program;" GRIP); 2) Pilot test GRIP in a small-scale randomized controlled trial (RCT) to obtain specific intervention parameters, including effect sizes and attrition rates, as well as preliminary efficacy data; and 3) Collect preliminary data on intervention moderators and mediators. To achieve these goals, we will conduct the proposed research in three stages. During the first stage, we will refine and standardize the GRIP manual. In the second stage, we will conduct an open, uncontrolled pilot test of the intervention on 6 patients. Following the open trial, we will develop a final version of the GRIP manual. In the third phase of the research, we will conduct a small pilot randomized controlled trial of GRIP (n=25) versus supportive counseling (SC; n=25) for individuals with FE schizophrenia spectrum disorders (i.e., schizophrenia; schizoaffective disorder; schizophreniform disorder). Participants will be assessed at baseline, mid-treatment, post-treatment, and three-month follow-up on a variety of outcome measures, including social functioning, substance use, medication attitudes and adherence, rehospitalization, and symptoms.

描述（由申请人提供）：拟议的研究有以下目标： 1）开发和标准化针对首发（FE）精神分裂症的基于手动的个体治疗，该治疗对初始精神病恢复的早期阶段敏感（即“分级恢复干预计划”；GRIP）； 2）在小规模随机对照试验（RCT）中对GRIP进行先导测试，以获得具体的干预参数，包括效应大小和损耗率，以及初步疗效数据； 3) 收集干预调节者和调解者的初步数据。为了实现这些目标，我们将分三个阶段进行拟议的研究。第一阶段，我们将细化和标准化GRIP手册。第二阶段，我们将对6名患者进行开放、非受控的干预先导测试。公开试用后，我们将开发 GRIP 手册的最终版本。在研究的第三阶段，我们将对 FE 精神分裂症谱系障碍（即精神分裂症；分裂情感性障碍；精神分裂样障碍）患者进行 GRIP（n=25）与支持性咨询（SC；n=25）的小型试点随机对照试验。参与者将在基线、治疗中期、治疗后和三个月随访时接受各种结果指标的评估，包括社会功能、药物使用、药物态度和依从性、再住院和症状。