Graduated Recovery Intervention for Early Schizophrenia

描述（由申请人提供）：拟议的研究具有以下目标：1）开发和标准化针对首发（FE）精神分裂症的基于手动的个体治疗，该治疗对初始精神病恢复的早期阶段（即，“渐进式康复干预计划”; 2）在小规模随机对照试验（RCT）中对GRIP进行初步测试，以获得具体的干预参数，包括效应量和损耗率，以及初步疗效数据;以及3）收集关于干预调节剂和中介剂的初步数据。为了实现这些目标，我们将分三个阶段进行拟议的研究。在第一阶段，我们将完善和标准化GRIP手册。在第二阶段，我们将对6名患者进行开放的、不受控制的干预试验。在公开试验之后，我们将开发GRIP手册的最终版本。在研究的第三阶段，我们将对FE精神分裂症谱系障碍（即，精神分裂症;情感障碍;精神分裂样障碍）。参与者将在基线、治疗中期、治疗后和三个月随访时接受各种结果指标的评估，包括社会功能、物质使用、用药态度和依从性、再住院和症状。

DESCRIPTION (provided by applicant): The proposed research has the following goals: 1) Develop and standardize a manual-based individual therapy for first-episode (FE) schizophrenia that is sensitive to the early stages of recovery from initial psychosis (i.e., the "Graduated Recovery Intervention Program;" GRIP); 2) Pilot test GRIP in a small-scale randomized controlled trial (RCT) to obtain specific intervention parameters, including effect sizes and attrition rates, as well as preliminary efficacy data; and 3) Collect preliminary data on intervention moderators and mediators. To achieve these goals, we will conduct the proposed research in three stages. During the first stage, we will refine and standardize the GRIP manual. In the second stage, we will conduct an open, uncontrolled pilot test of the intervention on 6 patients. Following the open trial, we will develop a final version of the GRIP manual. In the third phase of the research, we will conduct a small pilot randomized controlled trial of GRIP (n=25) versus supportive counseling (SC; n=25) for individuals with FE schizophrenia spectrum disorders (i.e., schizophrenia; schizoaffective disorder; schizophreniform disorder). Participants will be assessed at baseline, mid-treatment, post-treatment, and three-month follow-up on a variety of outcome measures, including social functioning, substance use, medication attitudes and adherence, rehospitalization, and symptoms.