Social Cognition and Interaction Training for Schizophrenia

描述(由申请人提供)：建议的项目是一个第三阶段的治疗发展研究，对社会认知和互动(SCIT)计划的有效性进行初步评估。SCIT是一种团体治疗，在六个月内每周提供50分钟的疗程。56名精神分裂症或分裂情感障碍患者将被随机分配到两种情况之一：1)SCIT(n=28)，或2)照常治疗(TAU)(n=28)。所有个人将继续接受常规医疗护理，包括抗精神病药物治疗。参与者必须符合DSM IV精神分裂症或分裂情感障碍的标准，不符合当前的物质依赖标准，并难以与他人互动。此外，参赛者必须年龄在25岁至60岁之间，男性或女性，任何种族背景，智商大于70。参与者将在基线、治疗后(6个月)和完成治疗后6个月就少数明确的结果(由于试点随机对照试验的规模较小)进行评估，包括社会认知、社会功能、生活质量和症状。临床医生对治疗手册的忠诚度将通过每周监督、对治疗过程进行录音和使用保真度量表来评估。关于偏执狂和神经认知的数据，潜在的调节变量，将在基线上收集。利益相关者(客户和治疗师)的反馈将仅在治疗后获得，以便为可能对治疗手册进行修订提供信息。

DESCRIPTION (provided by applicant): The proposed project is a phase 3 treatment development study to conduct a preliminary evaluation of the effectiveness of the Social Cognition and Interaction (SCIT) program. SCIT is a group treatment that is provided in 50-minute weekly sessions over six months. Fifty six individuals with schizophrenia or schizoaffective disorder will be randomly assigned to one of two conditions: 1) SCIT (n=28), or 2) Treatment as usual (TAU) (n=28). All individuals will continue to receive usual medical care for their disorder including antipsychotic medication. Participants must meet DSM IV criteria for schizophrenia or schizoaffective disorder, not meet current criteria for substance dependence, and have difficulty interacting with others. In addition, participants must be between the ages of 25-60, male or female, any ethnic background, and have an IQ greater than 70. Participants will be assessed at baseline, post-treatment (6 months), and 6 months after completing treatment on a small number of well-defined outcomes (due to the small size of the pilot RCT), including social cognition, social functioning, quality of life, and symptoms. Fidelity of clinicians to the treatment manual will be assessed by weekly supervision, audiotaping the therapy sessions, and utilization of fidelity scales. Data on paranoia and neurocognition, potential moderating variables, will be collected at baseline. Stakeholder (client and therapist) feedback will be obtained at post-treatment only, so as to inform possible revisions to the treatment manual.