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Social Cognition and Interaction Training for Schizophrenia

Social Cognition and Interaction Training for Schizophrenia
精神分裂症的社会认知和互动训练
批准号:
7425957
负责人:
DAVID Lewis PENN
金额:
$21.08万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-06-01 至 2010-05-31

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中文摘要
翻译
描述(由申请人提供):拟议项目是一项III期治疗开发研究,旨在对社会认知和互动(SCIT)计划的有效性进行初步评估。SCIT是一种团体治疗,每周50分钟,为期六个月。将56名精神分裂症或情感性精神障碍患者随机分配至以下两种情况之一:1)SCIT(n=28)或2)常规治疗(TAU)(n=28)。所有人将继续接受常规的医疗护理,包括抗精神病药物。参与者必须符合DSM IV精神分裂症或情感障碍的标准,不符合目前的物质依赖标准,并且难以与他人互动。此外,参与者必须年龄在25-60岁之间,男性或女性,任何种族背景,智商大于70。将在基线、治疗后(6个月)和完成治疗后6个月对参与者进行少量明确定义的结局(由于试点RCT的规模较小)评估,包括社会认知、社会功能、生活质量和症状。临床医生对治疗手册的忠实度将通过每周监督、对治疗过程进行录音和使用忠实度量表进行评估。将在基线时收集关于偏执狂和神经认知(潜在调节变量)的数据。仅在治疗后获得利益相关者(客户和治疗师)的反馈,以便告知治疗手册的可能修订。
英文摘要
DESCRIPTION (provided by applicant): The proposed project is a phase 3 treatment development study to conduct a preliminary evaluation of the effectiveness of the Social Cognition and Interaction (SCIT) program. SCIT is a group treatment that is provided in 50-minute weekly sessions over six months. Fifty six individuals with schizophrenia or schizoaffective disorder will be randomly assigned to one of two conditions: 1) SCIT (n=28), or 2) Treatment as usual (TAU) (n=28). All individuals will continue to receive usual medical care for their disorder including antipsychotic medication. Participants must meet DSM IV criteria for schizophrenia or schizoaffective disorder, not meet current criteria for substance dependence, and have difficulty interacting with others. In addition, participants must be between the ages of 25-60, male or female, any ethnic background, and have an IQ greater than 70. Participants will be assessed at baseline, post-treatment (6 months), and 6 months after completing treatment on a small number of well-defined outcomes (due to the small size of the pilot RCT), including social cognition, social functioning, quality of life, and symptoms. Fidelity of clinicians to the treatment manual will be assessed by weekly supervision, audiotaping the therapy sessions, and utilization of fidelity scales. Data on paranoia and neurocognition, potential moderating variables, will be collected at baseline. Stakeholder (client and therapist) feedback will be obtained at post-treatment only, so as to inform possible revisions to the treatment manual.
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