Proposal for a Chicago-CRIC Clinical Center

芝加哥-CRIC 临床中心提案

• 批准号: 7479529
• 负责人: JAMES P. LASH
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479529
• 关键词: Administrative Personnel; Adult; Advocate; African American; Albumins; American; Anthropometry; Area; Blood Pressure; Blood Tests; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Cessation of life; Chicago; Chronic; Chronic Kidney Failure; Chronic Kidney Insufficiency; Classification; Clinical; Clinical Research; Clinical Trials; Code; Cohort Studies; Collaborations; County; Data; Data Coordinating Center; Databases; Diabetes Mellitus; Echocardiography; Electron Beam; Electron Beam Tomography; End Point; End stage renal failure; Excretory function; Funding; Glomerular Filtration Rate; Goals; Growth; Health; Health Personnel; Healthcare; Human Resources; Hypertension; Illinois; Image; Incidence; Individual; Institution; Iothalamate; Kidney; Kidney Diseases; Kidney Failure; Laboratories; Lead; Measurement; Measures; Morbidity - disease rate; Nephrology; Numbers; Patient Recruitments; Patients; Performance; Population; Proteins; Publications; Questionnaires; Range; Reading; Recording of previous events; Records; Recruitment Activity; Renal function; Reporting; Research Personnel; Risk; Risk Factors; Sampling; Site; Testing; Time; Ultrasonography; United States National Institutes of Health; Universities; Urine; Visit; Woman; Work; Writing; base; cardiovascular imaging; computerized; cooking; design; disorder risk; experience; falls; follow-up; member; men; mortality; prospective; urinary

Individuals with chronic renal insufficiency (CRI) represent a large and growing segment of our population, with much of the recent growth fueled by the increased incidence of diabetes. The adverse impact of cardiovascular disease (CVD) in the end stage renal disease (ESRD) population has its beginnings earlier, during the course of CRI, but associated risk factors have not been completely characterized. The overlap between several CVD and renal disease risk factors suggests interactions between CRI and CVD that are not completely understood. The primary goals of the Prospective Cohort Study of Chronic Renal Insufficiency (CRIC) are to determine the risk factors for accelerated decline in renal function and to determine the incidence of, and identify risk factorsfor, cardiovascular disease in the CRI population. The proposed Chicago-CRIC Consortium is a group of closely tied institutions with a history of previous collaborations, serving a geographically compact and densely populated area, serving an adult patient population of several million among which an estimated 96,000 have CRI with GFRs in the range of 30-70 ml/min/1.73m2. Using our previously effective strategies in recruiting for theNIH- sponsored African American Study of Kidney Disease and Hypertension (AASK) and MEMO trials, we will recruit and retain 500 men and women with chronic renal insufficiency (CRI) from patients served by Chicago-CRIC institutions. The Chicago-CRIC Clinical Center will provide yearly Comprehensive Visits for six to seven years, which will include 125-iothalamate GFRs, blood pressure measurements, anthropometries, urine and blood testing, and cardiovascular imaging (electron beam tomograpy [EBT], echocardiography, and carotid ultrasound). In addition, we will provide regular morbidity and mortality follow-up, which will include the tracking and classification of renal and cardiovascular endpoints. The strengths of the Chicago-CRIC Clinical Center are the established history of collaboration between the member institutions, our experience as investigators in two previous large NIH multicenter clinical studies involving renal patients (AASK and HEMO), the utilization of an existing, NIH-funded General Clinical Research Center (GCRC) for all study visits, and our ability to access databases containing a very large CRI population.

患有慢性肾功能不全 (CRI) 的人在我们的人口中占很大一部分，而且还在不断增长，其中 最近的增长很大程度上是由糖尿病发病率的增加推动的。对心血管的不良影响 终末期肾病 (ESRD) 人群中的疾病 (CVD) 发病较早，发生在 CRI，但相关风险因素尚未完全确定。几种 CVD 之间的重叠 肾脏疾病危险因素表明 CRI 和 CVD 之间的相互作用尚不完全清楚。这 慢性肾功能不全前瞻性队列研究 (CRIC) 的主要目标是确定风险 肾功能加速下降的因素，确定其发生率并确定危险因素， CRI 人群中的心血管疾病。拟议中的芝加哥-CRIC 联盟是一个紧密联系的团体 具有先前合作历史的机构，服务于地理紧凑且人口稠密的地区 地区，为数百万成年患者提供服务，其中估计有 96,000 人患有 CRI 和 GFR 范围为30-70毫升/分钟/1.73平方米。使用我们以前有效的策略为 NIH 招募人员 赞助非洲裔美国人肾脏疾病和高血压研究 (AASK) 和 MEMO 试验，我们将招募 并保留芝加哥-CRIC 服务的 500 名患有慢性肾功能不全 (CRI) 的男性和女性患者 机构。芝加哥-CRIC 临床中心将在六到七年内每年提供综合就诊， 其中包括 125-碘酞酸盐 GFR、血压测量、人体测量、尿液和血液检测， 和心血管成像（电子束断层扫描 [EBT]、超声心动图和颈动脉超声）。在 此外，我们将提供定期的发病率和死亡率随访，其中包括跟踪和 肾脏和心血管终点的分类。芝加哥-CRIC 临床中心的优势是 成员机构之间建立了合作历史，我们作为两个研究人员的经验 先前涉及肾脏患者（AASK 和 HEMO）的大型 NIH 多中心临床研究，利用 现有的 NIH 资助的普通临床研究中心 (GCRC) 负责所有研究访问，并且我们有能力访问 包含大量 CRI 群体的数据库。