Clinical Outcomes Research: An Endoscopic Data Base

临床结果研究：内窥镜数据库

• 批准号: 7288342
• 负责人: DAVID A LIEBERMAN
• 金额: $ 72.23万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7288342
• 关键词: Adult; Anesthesia procedures; Applications Grants; Area; Attitude; Barrett Esophagus; Characteristics; Childhood; Clinical; Clinical Investigator; Clinical Research; Clinical effectiveness; Collaborations; Collection; Colonic Neoplasms; Communities; Community Practice; Computers; Daily; Data; Data Analyses; Data Files; Databases; Diagnosis; Diagnostic; Digestive System Disorders; Discipline; Disease; Effectiveness; Endoscopy; Ensure; Foundations; Funding; Gastroenterology; Gastrointestinal Diseases; Goals; Health Care Costs; Intervention; Knowledge; Measurement; Measures; Medical; Medical Surveillance; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Operative Surgical Procedures; Outcome; Outcome Study; Outcomes Research; Pathology; Patients; Pattern; Physicians; Play; Procedures; Propofol; Prospective Studies; Publishing; Quality Control; Quality of Care; Range; Recruitment Activity; Reflux; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Scientific Advances and Accomplishments; Site; Source; Therapeutic Intervention; Time; Translating; Translations; Ulcerative Colitis; United States; Variant; Work; base; capsule; computerized; data integrity; improved; innovation; pressure; programs; prospective; repository; research study; research to practice; success; tool

DESCRIPTION (PROVIDED BY APPLICANT): Pressure to improve the quality and lower the cost of health care has created the need to understand the effectiveness of medical interventions in clinical practice settings. Endoscopy plays an n important role in the diagnosis and management of digestive diseases. Despite widespread use of endoscopy, little is known about outcomes in community-based settings. We developed a practice-based consortium to study endoscopic outcomes. Practice sites utilize a computerized endoscopic report generator to produce endoscopy reports, while simultaneously creating a data file. De-identified endoscopy data is transmitted electronically from sites to a central data repository for data analysis. Quality control measures ensure data integrity and accuracy. The practice consortium now includes 648 physicians in 68 adult, and 11 pediatric practice sites in 28 states. Of all adult endoscopy results, 65 % come from non-academic settings. We have demonstrated successful completion of prospective research projects. In the current proposal, we will build on the foundation of our clinical practice network, to conduct research, which will improve the quality of clinical practice in gastroenterology. The specific themes of this proposal are: Theme 1: Analysis of practice. We will conduct prospective analysis of endoscopic utilization, measure endoscopic findings and complications, practice variation, and identify association, which predict likelihood of favorable or unfavorable outcomes. Theme 2: Translation of research into practice. We will conduct research projects to translate new information about endoscopic outcomes into clinical practice. The consortium provides a unique opportunity to determine hoe new discovery impacts practice. Theme 3: Prospective research. Prospective research will focus on areas of clinical practice that lack critical evidence of effectiveness. We have developed methods for collection of prospective data in the flow of practice, following patient outcomes over time, and measuring changes in practice over time. Theme 4: Provide a resource to the scientific community. We have demonstrated successful collaboration with a wide range of clinical investigators to develop projects that are uniquely suited to a large community-based practice network.

描述（由申请人提供）： 提高医疗质量和降低医疗成本的压力使得人们需要了解医疗干预措施在临床实践中的有效性。内镜在消化道疾病的诊断和治疗中起着重要作用。尽管内窥镜检查广泛使用，但对社区环境中的结果知之甚少。我们建立了一个以实践为基础的联盟来研究内镜结果。实践站点利用计算机化内窥镜报告生成器生成内窥镜报告，同时创建数据文件。去识别内镜检查数据以电子方式从研究中心传输到中央数据存储库进行数据分析。质量控制措施确保数据的完整性和准确性。实践联盟现在包括68个成人的648名医生和28个州的11个儿科实践地点。在所有成人内窥镜检查结果中，65%来自非学术机构。我们已经成功完成了预期的研究项目。在目前的建议中，我们将建立在我们的临床实践网络的基础上，进行研究，这将提高胃肠病学临床实践的质量。本提案的具体主题是：主题1：实践分析。我们将对内镜的使用进行前瞻性分析，测量内镜发现和并发症，实践变化，并确定相关性，预测有利或不利结局的可能性。主题2：将研究转化为实践。我们将开展研究项目，将有关内镜结果的新信息转化为临床实践。该联盟提供了一个独特的机会，以确定新发现的影响实践。主题三：前瞻性研究。前瞻性研究将集中在缺乏有效性关键证据的临床实践领域。我们已经开发了在实践流程中收集前瞻性数据的方法，随着时间的推移跟踪患者的结果，并测量实践中随着时间的推移而发生的变化。主题4：为科学界提供资源。我们已经证明了与广泛的临床研究人员成功合作，开发出独特适合大型社区实践网络的项目。