CLINICAL OUTCOMES RESEARCH: AN ENDOSCOPIC DATABASE

临床结果研究：内窥镜数据库

• 批准号: 6381729
• 负责人: DAVID A LIEBERMAN
• 金额: $ 84.87万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6381729
• 关键词: chronic disease /disorder; clinical research; community health services; cooperative study; diagnosis design /evaluation; endoscopy; gastrointestinal disorder; gastrointestinal disorder diagnosis; gastrointestinal imaging /visualization; health care personnel performance; health care quality; health services research tag; human data; human therapy evaluation; information dissemination; information systems; medical complication; outcomes research; pathologic process; patient /disease registry; patient care management

Pressure to improve quality and lower cost of health cre has created the need to understand the effectiveness of medical interventions, such as gastrointestinal (GI) endoscopy. Despite widespread use of endoscopic procedures, very little is known about endoscopic practice patterns and patient outcomes in community-based settings. The ideal method for studying endoscopic procedures is to go directly to the source: the endoscopy report. With the advent of computerized databases, it is now possible to generate endoscopic reports while simultaneously creating a data file. We have developed a network of GI specialists in diverse practice settings who utilize a common computerized endoscopic report generator. Endoscopic data from these Clinical Affiliates is transmitted electronically to a centralized data repository and merged with data from multiple Clinical Affiliates for analysis. These merged data can then be used to examine practice patterns and address important research questions. Based on extensive experience in building a clinical network for endoscopic research our group is unique able to meet the requirements stipulated in the current proposal. The primary goal of this proposal is to use the existing endoscopic database to acquire information that will improve the quality of clinical practice in gastroenterology. The specific aims of this proposal are to use the endoscopic database to: . Perform descriptive analyses of utilization, frequency and severity of endoscopic findings, practice patterns, practice variation (geographic region, type of clinical practice), and patient demographics (age, gender, race). . Use descriptive analyses to form the basis for developing hypotheses and risk stratification. . Observe the natural history of chronic GI diseases, and determine appropriate intervals for surveillance. . Determine the success and effectiveness of endoscopic therapies and new endoscopic innovations. . Determine the impact of endoscopic diagnoses and therapies on patient outcomes. . Evaluate the frequency of endoscopic complications, and risk factors for complications. . Use the database for specific research projects and to create patient registries for clinical trials.

提高医疗质量和降低医疗成本的压力催生了了解胃肠道 (GI) 内窥镜检查等医疗干预措施有效性的需求。尽管内窥镜手术被广泛使用，但人们对社区环境中的内窥镜实践模式和患者结果知之甚少。研究内窥镜检查程序的理想方法是直接查找来源：内窥镜检查报告。随着计算机化数据库的出现，现在可以在创建数据文件的同时生成内窥镜报告。我们在不同的实践环境中建立了一个由胃肠道专家组成的网络，他们使用通用的计算机内窥镜报告生成器。来自这些临床附属机构的内窥镜数据以电子方式传输到中央数据存储库，并与来自多个临床附属机构的数据合并进行分析。然后，这些合并的数据可用于检查实践模式并解决重要的研究问题。基于建立内窥镜研究临床网络的丰富经验，我们小组能够满足当前提案中规定的要求。该提案的主要目标是利用现有的内窥镜数据库获取信息，以提高胃肠病学临床实践的质量。该提案的具体目标是使用内窥镜数据库来：对内窥镜检查结果的利用率、频率和严重程度、实践模式、实践变化（地理区域、临床实践类型）和患者人口统计（年龄、性别、种族）进行描述性分析。 。使用描述性分析形成假设和风险分层的基础。 。 观察慢性胃肠道疾病的自然史，并确定适当的监测间隔。 。确定内窥镜治疗和新内窥镜创新的成功和有效性。 。确定内窥镜诊断和治疗对患者预后的影响。 。评估内镜并发症的发生频率以及并发症的危险因素。 。使用该数据库进行特定研究项目并创建临床试验患者登记。