Goblet cell stress and intestinal inflammation

杯状细胞应激和肠道炎症

• 批准号: nhmrc : 488809
• 负责人: A/Pr Graham Radford-Smith
• 金额: $ 38.1万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/goblet-cell-stress-intestinal-inflammation/77703
• 关键词: Goblet; cell; stress; intestinal; inflammation

We have generated mice with symptoms mirroring the inflammatory bowel disease, ulcerative colitis (UC). These mice have mutations in the gene producing the major component of the protective mucus layer in the intestine. The mutations lead to a phenomenon known as ER stress. We have shown that ER stress also occurs in UC, opening up a new understanding of this disease. The proposed research will explore links between ER stress and inflammation and test potential new treatments for UC.

我们已经产生了具有反映炎性肠病、溃疡性结肠炎（UC）的症状的小鼠。这些小鼠在产生肠道保护性粘液层的主要成分的基因中有突变。这些突变导致了一种被称为ER应激的现象。我们已经表明，ER应激也发生在UC中，开辟了对这种疾病的新认识。这项研究将探索ER应激与炎症之间的联系，并测试UC的潜在新疗法。