Interactions between host and the gut microbiome in the pathogenesis of ankylosing spondylitis and Crohn's disease

强直性脊柱炎和克罗恩病发病机制中宿主与肠道微生物组之间的相互作用

• 批准号: nhmrc : 1065509
• 负责人: A/Pr Graham Radford-Smith
• 金额: $ 38.16万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-host-gut-crohns-disease/455178
• 关键词: Interactions; between; host; gut; microbiome

Ankylosing spondylitis (AS) and Crohn's disease (CD) are common immune-mediated diseases affecting primarily the joints of the spine and the gut respectively. Genes play a major role in determining the risk of each disease, and it is likely that those genes cause the disease by interaction with some environmental factor, most likely bacteria residing in the gut. This study aims to test that hypothesis by profiling the bacteria in the gut of patients with the diseases and healthy subjects.

强直性脊柱炎（AS）和克罗恩病（CD）是常见的免疫介导性疾病，主要分别影响脊柱关节和肠道。基因在决定每种疾病的风险方面起着重要作用，这些基因很可能通过与某些环境因素（最有可能是肠道中的细菌）相互作用而导致疾病。这项研究旨在通过分析患病患者和健康受试者肠道中的细菌来验证这一假设。