ASSESSMENT OF ENDOPLASMIC RETICULUM STRESS AND MUTATIONS IN MUCIN OLIGOMERIZATION DOMAINS IN ULCERATIVE COLITIS

溃疡性结肠炎内质网应激和粘蛋白寡聚化结构域突变的评估

• 批准号: nhmrc : 511204
• 负责人: A/Pr Graham Radford-Smith
• 金额: $ 19.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assessment-endoplasmic-reticulum-ulcerative-colitis/81326
• 关键词: ASSESSMENT; ENDOPLASMIC; RETICULUM; STRESS; MUTATIONS

Ulcerative colitis affects 0.2% of Australians causing chronic or recurrent health morbidity and affecting employment. In severe cases it is life threatening. Its pathogenesis remains poorly understood. We have exciting and novel preliminary data from humans and informed by our unique animal models that make us propose that the disease is caused by Endoplasmic Reticulum Stress due to misfolding of mucin. We have designed fully powered prospective clinical and lab studies to test this hypothesis.

溃疡性结肠炎影响0.2%的澳大利亚人，导致慢性或复发的健康发病率，并影响就业。在严重的情况下，它会危及生命。其发病机制尚不清楚。我们有来自人类的令人兴奋和新颖的初步数据，以及我们独特的动物模型的信息，这些数据使我们提出这种疾病是由粘蛋白错误折叠引起的内质网应激引起的。我们已经设计了完全有效的前瞻性临床和实验室研究来验证这一假设。