Hookworm Therapy in Coeliac Disease (CeD), Phase 1b

腹腔疾病 (CeD) 钩虫疗法，1b 期

• 批准号: nhmrc : 1105300
• 负责人: A/Pr Graham Radford-Smith
• 金额: $ 59.72万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hookworm-therapy-coeliac-phase-1b/662816
• 关键词: Hookworm; Therapy; Coeliac; Disease; CeD

Parasitic worms have an amazing ability to manipulate the immune system, and our research group recently discovered how they may hold the key for treating inflammatory diseases such as Coeliac Disease. The aim of my research is to further develop this novel therapy in a clinical trial and study the mechanism of how worms control the immune response, including identifying the molecules that the worm produces that could be produced as a pill-based medication for treating coeliac disease.

寄生蠕虫具有操纵免疫系统的惊人能力，我们的研究小组最近发现了它们如何成为治疗炎症性疾病（如腹腔疾病）的关键。我研究的目的是在临床试验中进一步开发这种新疗法，并研究蠕虫如何控制免疫反应的机制，包括鉴定蠕虫产生的分子，这些分子可以作为治疗腹腔疾病的药丸药物。