The Role of Paneth Cells in Ileal Crohns Disease

潘氏细胞在回肠克罗恩病中的作用

• 批准号: nhmrc : 498405
• 负责人: A/Pr Graham Radford-Smith
• 金额: $ 15.32万
• 依托单位: Royal Brisbane and Women's Hospital Research Foundation
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-paneth-cells-crohns-disease/98039
• 关键词: Role; Paneth; Cells; Ileal; Crohns

Crohn's disease is a severe, chronic inflammatory disease of the gut which affects up to 50,000 Australians. The majority of patients develop the disease in their twenties, with significant impact on their quality of life. Our preliminary work has identified a novel gene, which could potentially cause a critical reduction in the production of anti-bacterial proteins by cells in the small bowel. Exploring the function of this gene in relation to clinical outcome could lead to better treatment.

克罗恩病是一种严重的慢性肠道炎症性疾病，影响多达5万澳大利亚人。大多数患者在20多岁时患上这种疾病，严重影响了他们的生活质量。我们的初步工作已经确定了一个新的基因，它可能会导致小肠细胞产生的抗菌蛋白严重减少。探索该基因的功能与临床结果的关系可能会带来更好的治疗。