Pediatric Graft-vs-Host Disease

儿童移植物抗宿主病

• 批准号: 7292872
• 负责人: alan s wayne
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7292872
• 关键词: Pediatric; Graft; vs; Host; Disease

The primary goal is to advance understanding of the pathobiology and natural history of and to develop new strategies to prevent and treat graft-versus-host disease in pediatric patients. This is a collaborative project with the NCI Experimental Transplantation Immunology Branch and multiple NIH Intramural Investigators. The following projects/efforts are currentlyunderway: 1) Natural History Study of GVHD; 2) Bench-to-Bedside Translational Development of Extracorporeal Photophersis for childrenwith chronic GVHD; 3) National Working Groups to Develop Diagnostic Standards and Supportive Care Guidelines; 4) Novel Therapeutics for GVHD

主要目的是促进对儿科患者移植物抗宿主病的病理生物学和自然史的理解，并制定预防和治疗儿科患者移植物抗宿主病的新策略。这是一个与NCI实验移植免疫学分支和多个NIH校内研究者的合作项目。目前正在进行的项目有：1）GVHD的自然史研究; 2）慢性GVHD患儿体外光疗法的临床转化研究; 3）国家工作组制定诊断标准和支持性护理指南; 4）GVHD的新疗法