Pediatric Graft-vs-Host Disease

儿童移植物抗宿主病

• 批准号: 7969943
• 负责人: alan s wayne
• 金额: $ 32.46万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7969943
• 关键词: Adolescent; Adult; Allogenic; Child; Childhood; Chronic; Data; Development; Diagnostic; Disease; Disease-Free Survival; Goals; Growth; Guidelines; Hematopoietic Stem Cell Transplantation; Life; Morbidity - disease rate; Natural History; Organ; Patients; Pediatrics; Population; Recurrence; Research; Research Personnel; Stem cell transplant; Supportive care; Transplantation; Transplantation Immunology; United States National Institutes of Health; bench to bedside; chronic graft versus host disease; graft vs host disease; mortality; novel therapeutics; prevent; response; working group

The primary goal is to advance understanding of the pathobiology and natural history of and to develop new strategies to prevent and treat graft-versus-host disease in pediatric patients. This is a collaborative project with the NCI Experimental Transplantation Immunology Branch and multiple NIH Intramural Investigators. The following projects/efforts are currently underway: 1) Natural History Study of GVHD; 2) Bench-to-Bedside Translational Development of Extracorporeal Photophersis for childrenn with chronic GVHD; 3) National Working Groups to Develop Diagnostic Standards and Supportive Care Guidelines; 4) Novel Therapeutics for GVHD

主要目标是增进对儿科患者移植物抗宿主病的病理学和自然史的了解，并制定预防和治疗移植物抗宿主病的新策略。这是与 NCI 实验移植免疫学分支和多名 NIH 校内研究人员的合作项目。目前正在进行以下项目/工作：1）GVHD 的自然历史研究； 2) 慢性 GVHD 儿童体外光流通术从实验室到床边的转化开发； 3) 制定诊断标准和支持性护理指南的国家工作组； 4) GVHD 的新疗法