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HIV Infection In Vivo And In Vitro

HIV Infection In Vivo And In Vitro
HIV 体内和体外感染
批准号：
7299815
负责人：
Richard A Koup
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7299815
关键词：
HIVInfectionVivoVitro

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中文摘要
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英文摘要
HIV is known to primarily replicate in activated CD4+ T cells. In vitro studies have assessed the ability of HIV to replicate in multiple subsets of CD4+ T cells, and have identified several potential sources of T cells that are subject to infection by HIV. However, it remains unclear which CD4+ T cells are most frequently infected in vivo, and the impact of infection of these various subsets. This study seeks to define the subsets of CD4+ T cells that are naturally infected in patients, and the impact upon HIV and pathogen-specific immunity and the latent reservoir of HIV.
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Tfh and B cells in HIV/SIV pathogenesis and vaccination
Tfh and B cells in HIV/SIV pathogenesis and vaccination
Immune Reconstitution
T Cell Immune Responses To HIV And Other Pathogens
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