T Cell Immune Responses To HIV And Other Pathogens

T 细胞对 HIV 和其他病原体的免疫反应

• 批准号: 8336373
• 负责人: Richard A Koup
• 金额: $ 127.39万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336373
• 关键词: Failure; HIV; Immune response; Immunologics; Phenotype; T-Lymphocyte; Vaccines; Virus; pathogen; response; success; vaccine development

We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

我们还没有完全确定与HIV复制的免疫控制相关的免疫反应。为了开发有效的疫苗，我们需要更好地了解可能控制艾滋病毒的反应，以及为什么这些防御可能失败。这项研究检查了自然感染受试者对艾滋病毒的T细胞免疫反应。它将这些反应与针对其他病毒和非病毒病原体产生的反应进行比较，以确定免疫反应成功或失败的机制。