Immune Reconstitution

免疫重建

• 批准号: 7732736
• 负责人: Richard A Koup
• 金额: $ 66.64万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732736
• 关键词: Affect; Bone Marrow; Cell Count; Future; Goals; HIV; HIV Infections; Highly Active Antiretroviral Therapy; Immune; Immune response; Immunity; Individual; Interleukin-7; Intervention; Lead; Organ; Patients; Rate; Recovery; Role; T-Lymphocyte; Therapeutic; Thymus Gland; Vaccination; Virus Replication; cytokine; design; improved; reconstitution

In HIV-infected patients treated with HAART, there are variable rates of reconstitution of T cell numbers and function. An understanding of the mechanisms underlying the recovery of T cells will be important for the design of future strategies to improve T cell reconstitution. The thymus is the organ responsible for producing new naive T cells with a broad immune repertoire from bone marrow-derived precursors. IL-7 is a cytokine that has direct effects upon the thymus and naive T cells. This study examines the role of the thymus in HIV infection and immune reconstitution, and how IL-7 can affect that role.This study seeks to improve our understanding of how HAART affects the immune response to HIV, and how therapeutic vaccination, with or without additional interventions, will lead to improved immunity against HIV and better control of virus replication.

在接受HAART治疗的HIV感染患者中，T细胞数量和功能的重建率存在差异。了解 T 细胞恢复的机制对于设计未来改善 T 细胞重建的策略非常重要。胸腺是负责从骨髓来源的前体产生具有广泛免疫库的新初始 T 细胞的器官。 IL-7 是一种细胞因子，对胸腺和初始 T 细胞有直接作用。本研究探讨了胸腺在 HIV 感染和免疫重建中的作用，以及 IL-7 如何影响该作用。本研究旨在提高我们对 HAART 如何影响 HIV 免疫反应的理解，以及治疗性疫苗接种（无论是否有额外干预）如何提高对 HIV 的免疫力并更好地控制病毒复制。

项目成果

Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development.

成人肝脏含有具有幼稚表型的 CD8pos T 细胞，但不是传统 αβ T 细胞发育的场所。

• DOI: 10.4049/jimmunol.172.10.5980
• 发表时间: 2004
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Golden-Mason,Lucy;Douek,DanielC;Koup,RichardA;Kelly,Jacinta;Hegarty,JohnE;O'Farrelly,Cliona
• 通讯作者: O'Farrelly,Cliona