HIV Infection In Vivo And In Vitro

HIV 体内和体外感染

• 批准号: 7592385
• 负责人: Richard A Koup
• 金额: $ 121.38万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7592385
• 关键词: CD4 Positive T Lymphocytes; HIV; HIV Infections; Immune response; Immunity; In Vitro; Infection; Patients; Source; T-Lymphocyte; Vaccines; cell type; in vivo; pathogen

HIV is known to primarily replicate in activated CD4+ T cells. In vitro studies have assessed the ability of HIV to replicate in multiple subsets of CD4+ T cells, and have identified several potential sources of T cells that are subject to infection by HIV. However, it remains unclear which CD4+ T cells are most frequently infected in vivo, and the impact of infection of these various subsets. This study seeks to define the subsets of CD4+ T cells that are naturally infected in patients, and the impact upon HIV and pathogen-specific immunity and the latent reservoir of HIV.

已知HIV主要在活化的CD4+ T细胞中复制。体外研究已经评估了HIV在多个CD4+ T细胞亚群中复制的能力，并且已经鉴定了受HIV感染的T细胞的几种潜在来源。然而，目前还不清楚哪些CD4+ T细胞在体内最常被感染，以及这些不同亚群感染的影响。本研究旨在确定患者自然感染的CD4+ T细胞亚群，以及对HIV和病原体特异性免疫的影响和HIV的潜在储存库。