Hiv Infection In Vivo And In Vitro

体内和体外艾滋病毒感染

• 批准号: 6822213
• 负责人: Richard A Koup
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6822213
• 关键词: HIV infections; cell population study; clinical trials; disease reservoirs; ethnic group; flow cytometry; helper T lymphocyte; human subject; immunologic memory; latent virus infection; leukocyte activation /transformation; patient oriented research; polymerase chain reaction; thymus; tissue /cell culture; virus replication

We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

我们还没有完全定义与免疫控制HIV复制相关的免疫反应。为了开发一种有效的疫苗，我们需要更好地了解可能控制艾滋病毒的反应，以及为什么这些防御措施可能失败。这项研究检测了自然感染的受试者对HIV的T细胞免疫反应。它将这些反应与针对其他病毒和非病毒病原体产生的反应进行比较，以确定免疫反应成功或失败的机制。