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Hiv Infection In Vivo And In Vitro

Hiv Infection In Vivo And In Vitro
体内和体外艾滋病毒感染
批准号：
6822213
负责人：
Richard A Koup
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6822213
关键词：
HIV infections cell population study clinical trials disease reservoirs ethnic group flow cytometry helper T lymphocyte human subject immunologic memory latent virus infection leukocyte activation /transformation patient oriented research polymerase chain reaction thymus tissue /cell culture virus replication

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英文摘要
We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.
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会议论文
Tfh and B cells in HIV/SIV pathogenesis and vaccination
Immune Reconstitution
Tfh and B cells in HIV/SIV pathogenesis and vaccination
Pre-clinical Vaccine Development for Respiratory Viruses