Murine Genetics and Physiology Core

小鼠遗传学和生理学核心

• 批准号: 7217668
• 负责人: MONTY KRIEGER
• 金额: $ 39.83万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7217668
• 关键词: animal breeding; animal colony; biomedical facility; disease /disorder model; electrocardiography; gene deletion mutation; genetically modified animals; genotype; molecular genetics; transfection /expression vector

The application of murine molecular genetics (including transgenic and chimeric approaches) and physiologic (and pathophysiologic) analysis of murine models of disease is a major feature of all of the Projects in this Program. All of the Projects require a great deal of complex breeding of mice, involving genotyping and tracking multiple genes. Furthermore, there are multiple common murine physiologic methods used throughout the Program. The Murine Genetics and Physiology Core will be invaluable in streamlining and making available in the most cost-effective manner these approaches to all of the Projects.

小鼠分子遗传学(包括转基因和嵌合体方法)和 对小鼠疾病模型的生理学(和病理生理学)分析是所有项目的一个主要特征 在本节目中。所有这些项目都需要大量复杂的老鼠繁育工作，包括基因分型和 追踪多个基因。此外，还有多种常见的小鼠生理学方法贯穿始终。 该计划。小鼠遗传学和生理学核心将在简化和提供 以最具成本效益的方式将这些方法应用于所有项目。