Murine Genetics and Physiology Core

小鼠遗传学和生理学核心

• 批准号: 7217668
• 负责人: MONTY KRIEGER
• 金额: $ 39.83万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7217668
• 关键词: animal breeding; animal colony; biomedical facility; disease /disorder model; electrocardiography; gene deletion mutation; genetically modified animals; genotype; molecular genetics; transfection /expression vector

The application of murine molecular genetics (including transgenic and chimeric approaches) and physiologic (and pathophysiologic) analysis of murine models of disease is a major feature of all of the Projects in this Program. All of the Projects require a great deal of complex breeding of mice, involving genotyping and tracking multiple genes. Furthermore, there are multiple common murine physiologic methods used throughout the Program. The Murine Genetics and Physiology Core will be invaluable in streamlining and making available in the most cost-effective manner these approaches to all of the Projects.

小鼠分子遗传学（包括转基因和嵌合方法）的应用， 对疾病的小鼠模型进行生理学（和病理生理学）分析是所有项目的主要特征 在这个节目中。所有这些项目都需要大量复杂的小鼠繁殖，包括基因分型和 追踪多个基因此外，有多种常见的鼠生理学方法贯穿使用， 节目小鼠遗传学和生理学核心将是非常宝贵的精简和提供， 以最具成本效益的方式对所有项目采用这些方法。