Murine Genetics and Physiology Core

小鼠遗传学和生理学核心

• 批准号: 7217668
• 负责人: MONTY KRIEGER
• 金额: $ 39.83万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7217668
• 关键词: animal breeding; animal colony; biomedical facility; disease /disorder model; electrocardiography; gene deletion mutation; genetically modified animals; genotype; molecular genetics; transfection /expression vector

The application of murine molecular genetics (including transgenic and chimeric approaches) and physiologic (and pathophysiologic) analysis of murine models of disease is a major feature of all of the Projects in this Program. All of the Projects require a great deal of complex breeding of mice, involving genotyping and tracking multiple genes. Furthermore, there are multiple common murine physiologic methods used throughout the Program. The Murine Genetics and Physiology Core will be invaluable in streamlining and making available in the most cost-effective manner these approaches to all of the Projects.

鼠分子遗传学的应用（包括转基因和嵌合的方法）和 疾病鼠模型的生理学（和病理生理学）分析是所有项目的主要特征 在这个程序中。所有项目都需要大量的复杂繁殖小鼠，涉及基因分型和 跟踪多个基因。此外，整个过程中都有多种常见的鼠生理方法 该程序。鼠类遗传学和生理核心将在精简和提供中无价 这些方法对所有项目的最具成本效益的方式。